“EVALUATION OF ANTIHYPERGLYCEMIC EFFECT OF OXALIS LATIFOLIA KUNTH IN STREPTOZOTOCIN - INDUCED DIABETIC RATS”
Arunkumar Subramanian*, Suganya V N, Venkateswaran V
Dept. of Pharmacology, J.K.K.Nattraja College of Pharmacy, Kumarapalayam, Tamilnadu, India.
The ethanolic extract of Oxalis latifolia Kunth was evaluated for antihyperglycemic activity against streptozotocin-induced diabetic rats. The blood glucose level at various time intervals of 0, 1, 2 and 3 hours after the administration of ethanolic extract of Oxalis latifolia Kunth was calculated. It decreased the blood glucose levels significantly from 334.64±5.14 to 137.94±5.04 at 3 hours after the administration of 200 mg/kg of ethanolic extract and from 333.65±6.04 to 122.68±6.44 at 3 hours after the administration of 400 mg/kg of ethanolic extract. The antihyperglycemic activity was evaluated in comparison of the administration of an oral hypoglycemic agent, Tolbutamide which decreased the blood glucose level from 327.48±6.91 to 112.26±3.09 after 3 hours of administration. The results provide promising baseline information for the potential use of ethanolic extract of whole plants of Oxalis latifolia Kunth as an anti-hyperglycemic agent.