IAJPR

Indo American Journal of Pharmaceutical Research

ISSN NO.: 2231-6876
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OCTOBER 2019
1

“EVALUATION OF ANTIHYPERGLYCEMIC EFFECT OF OXALIS LATIFOLIA KUNTH IN STREPTOZOTOCIN - INDUCED DIABETIC RATS”

Arunkumar Subramanian*, Suganya V N, Venkateswaran V
Dept. of Pharmacology, J.K.K.Nattraja College of Pharmacy, Kumarapalayam, Tamilnadu, India.

The ethanolic extract of Oxalis latifolia Kunth was evaluated for antihyperglycemic activity against streptozotocin-induced diabetic rats. The blood glucose level at various time intervals of 0, 1, 2 and 3 hours after the administration of ethanolic extract of Oxalis latifolia Kunth was calculated. It decreased the blood glucose levels significantly from 334.64±5.14 to 137.94±5.04 at 3 hours after the administration of 200 mg/kg of ethanolic extract and from 333.65±6.04 to 122.68±6.44 at 3 hours after the administration of 400 mg/kg of ethanolic extract. The antihyperglycemic activity was evaluated in comparison of the administration of an oral hypoglycemic agent, Tolbutamide which decreased the blood glucose level from 327.48±6.91 to 112.26±3.09 after 3 hours of administration. The results provide promising baseline information for the potential use of ethanolic extract of whole plants of Oxalis latifolia Kunth as an anti-hyperglycemic agent. 


 


2

COMPARATIVE INSILLICO STUDIES ON PHYTOCHEMICALS OF OCIMUM AS NATURAL INHIBITORS OF EBOLA VP-35 PROTEIN

Srinidhi Kashyap*
Department of Biotechnology, Ramaiah Institute of Technology, Bangalore, Karnataka, India.

Ebola is a deadly single-stranded negative-sense RNA virus capable of causing hemorraghic fever and death in human and non-human primates. Ebola outbreaks worldwide have claimed a staggering 28000 lives and this virus could be used as a bioweapon for its high rate of transmission and fatality. Most importantly, the virus is unreceptive to a wide range of antiviral drugs and therapies. VP-24, VP-30, VP-35, and VP-40 are some of the important structural proteins of Ebola. VP-35 is a multifunctional structural protein of EBOLA and is crucial for its life processes. Exhaustive data-mining and literature survey was used to identify all the phytochemicals of the genus Ocimum and the control ligands against VP-35. Gossypetin, Gummosin, Limonin, and Taxifolin were the identified control ligands. ADME-TOX screening was employed to screen and shortlist phytochemicals for insillico studies. Comparative molecular docking simulation of the screened phytochemicals was performed primarily using iGEMDOCKv2.1 and further redocking simulation was performed using AutoDock Vina. Insillico studies on the 60 drug-likeness screened ligands yielded Cosmosiin (-7.2 kcal/mol), Molludistin (-7.1 kcal/mol) and Isovitexin (-7 kcal/mol) from Ocimum as the best ligands against VP-35. The control ligands were ranked as follows, Gummosin (-7.8 kcal/mol), Taxifolin (-7 kcal/mol), Gossypetin (-7 kcal/mol) and Limonin (-6.9 kcal/mol). Summarizing the results, Cosmosiin and Molludistin have superior binding affinities with VP-35 than 75% (3 out of 4) of the studied control ligands and these top-ranked phytochemicals of Ocimum identified could be used as efficient plant-based drug candidates to short-circuit the drug development phase and develop potent inhibitors against VP-35. 


 


3

CONVENTIONAL AND ALTERNATIVE MEASURES FOR IBS MANAGEMENT

Abdul Kader Mohiuddin
Dr. M. Nasirullah Memorial Trust, Tejgaon, Dhaka.

Irritable bowel syndrome (IBS) or irritable bowel disease (IBD), is also known as spastic colitis, mucus colitis, and nervous colon. It is a chronic, or long-term, condition, but symptoms tend to change over the years. It’s not uncommon for people with IBS to have episodes of both constipation and diarrhea. Symptoms such as bloating and gas typically go away after a bowel movement. There is no cure for IBS. Treatment is aimed at symptom relief. Certain foods as well as stress and anxiety can be triggers for IBS symptoms for many people. Medications are available to ease the symptoms of IBS, but some patients feel better trying natural remedies instead of (or in addition to) conventional drugs. Objective of the Study: To detail conventional and alternative treatment approaches of IBS. Limitation of The Study: Surgical considerations of IBS patients are not included in this article. Findings: Lifestyle modification, specially food habit alteration mostly effective along with psychological counseling and medication adherence. Practical Implications: GPs, gastroenterologists, medicine specialists, pharmacy and medical students will get best benefit out of this article. 


 


4

DEVELOPMENT AND EVALUATION OF MICROBALLOONS OF IBUPROFEN

Bhumi Bhavsar*,Snehal Patel, Chintan Aundhia, Avinash Seth, Nirmal Shah, Dipti Gohil, Kartik Pandya
Department of Pharmacy, Sumandeep Vidyapeeth, Vadodara, India.

In present study an attempt was made to prepare microballoons of ibuprofen by emulsion solvent diffusion technique for sustained delivery by using polymers like Ethyl cellulose to extend the drug release for about 12 hours in the upper GIT, which may result in enhanced absorption and there by improved bioavailability. Development of ibuprofen loaded microballoons was carried out by using different concentration of Polyvinyl alcohol (PVA) and Ethyl cellulose. Total four batches were formulated. All four batches were evaluated for Yield and entrapment efficiency Among all batches F2 shows maximum Yield and entrapment efficiency and was considered as optimized formulation. Optimized batch F2 was evaluated for Zeta Potential, Particle Size Distribution SEM and stability study. 


 


5

EVALUATION OF ANTI-DIABETIC AND ANTI-HYPERLIPIDEMEDIC ACTIVITY OF CRATAEVA NURVALA (BUCH-HAM.) LEAVES AND ROOT BARK METHANOLIC AND AQUEOUS EXTRACT

Safoora Naaz*, Dr. Syed Yousuf Hussain, Dr. Venkateshwar Reddy, Asma Khanam
Anwarul Uloom College of Pharmacy, Mallepally, Hyderabad, Telangana State, India.

Diabetes and Hyperlipidemic disease effects many people around the world and their development is a result of the high glucose level and high cholesterol levelin many of the people effecting with cardiac arrest and myocardial infarction. The presence of various phytoconstituent such as glycosides, tannins, flavonoids, saponins, alkaloids, steroids, and triterpeniods were evident in CNLE and CNRBE. The presence study was undertaken to investigate the anti diabetic and anti hyperlipidemic effect of Crataeva nurvala leaves and Root bark of CNLE and CNRBE (250 and 500mg /kg, b.w , p.o) respectively following 7- days treatment in streptozotocin induced in albino wistar mice and 31 days treatment in Triton X-100 induced model in albino wistar rats. Metformin HCL 10mg/kg was taken as standard and Streptozotocin and Atrovastatin 10mg/kg was taken standard Triton X-100 was taken as inducers as drugs. The Diabetic effect of the extract is attributed to have lowered the glucose level and Hyperlipidemic effect of extract is attributed to have lower cholesterol level in histological studies. The anti diabetic and hyperlipidemic activity is recognized by a reduction in glucose and cholesterol level. 


 


6

METHOD DEVELOPMENT AND STATISTICAL VALIDATION OF VALSARTAN IN BULK AND TABLET DOSAGE FORM BY UV SPECTROPHOTOMETRIC METHOD

G. Krishnamoorthy*, N Siva Subramanian, R. Senthamarai, T.M. FarhathHaseena, P. Buvaneswari
Periyar College of Pharmaceutical Sciences, Trichy-21, Tamil Nadu, India.

A simple, accurate, specific and precise UV Spectrophotometric method has been developed for estimation of Valsartan in bulk and pharmaceutical formulation. The ? max of Valsartan in ethanol was found to be 249 nm. The drug exhibited the linearity in the concentration range of 10-60?g/mL with correlation coefficient of 0.999. the % recovery of the drug for the proposed was found to be between 99.82 to 100.48%. The % RSD values found to be less than 2. No interference was observed in the presence of common pharmaceutical excipients. The method was validated as per ICH guidelines. The developed method was successfully employed for the estimation of Valsartan in pharmaceutical dosage form. The developed method was cost effective with less consumption of solvents and can be used for routine analysis.