Besides being a rich for vitamins and fibre, the skin and seeds of grapes are highly rich in Polyphenols specifically proanthocyanidins, which can be used as a functional ingredient to address various health issues by boosting the natural bio-processes of the body. Antioxidant power of proanthocyanidins is 20 times greater than vitamin E and 50 times greater than vitamin C. Proanthocyanidins in Grape seeds have been shown to exhibit strong antioxidant, antimutagenic, anti-inflammatory, anticarcinogenic and antiviral activity. Through different and various studies, it was proved that the proanthocyanidin rich grape seed extract provides benefits against many diseases i.e. inflammation, cardiovascular disease, hypertension, diabetes, cancer, peptic ulcer, microbial infections, etc. Therefore, beside from using it as a nutraceutical or cosmeceutical, as a result they may have a potential to substitute or complement in currently used drugs in the treatment of diseases by developing it into other successful pharmaceutical formulations for better future prospective. This current review, disscussed about the grapeseed extract uses, its formulation into tablet dosage form and evaluation parameters.Besides being a rich for vitamins and fibre, the skin and seeds of grapes are highly rich in Polyphenols specifically proanthocyanidins, which can be used as a functional ingredient to address various health issues by boosting the natural bio-processes of the body. Antioxidant power of proanthocyanidins is 20 times greater than vitamin E and 50 times greater than vitamin C. Proanthocyanidins in Grape seeds have been shown to exhibit strong antioxidant, antimutagenic, anti-inflammatory, anticarcinogenic and antiviral activity. Through different and various studies, it was proved that the proanthocyanidin rich grape seed extract provides benefits against many diseases i.e. inflammation, cardiovascular disease, hypertension, diabetes, cancer, peptic ulcer, microbial infections, etc. Therefore, beside from using it as a nutraceutical or cosmeceutical, as a result they may have a potential to substitute or complement in currently used drugs in the treatment of diseases by developing it into other successful pharmaceutical formulations for better future prospective. This current review, disscussed about the grapeseed extract uses, its formulation into tablet dosage form and evaluation parameters. 

Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits -sterol reductase and cholestenol ?-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.This paper describes a simple, accurate, specific and validated method for the estimation of amorolfine hydrochloride in ointment form. A study was carried out of all the parameters established as per ICH guidelines to validate an analytical method for estimation. The method showed high sensitivity with reproducibility in results. The wavelength maxima (?max) was found to be 219 nm. The linearity for this method was found to be in the range of 05 – 30 ?g/ml. The calibration curve (Fig -2) was drawn by plotting graph between absorbance and concentration. This method showed a correlation coefficient of 0.9997. The regression equation of the curve was Y= 0.0227x+0.02641. Method was successfully validated. In addition, this proposed method was simple, sensitive, Easy to apply and requires relatively inexpensive instruments. The proposed method can be used for routine analysis of amorolfine Hydrochloride in bulk as well as in the commercial formulations. 

Antibiotic resistance is considered one of the world's major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms. From these reviews we synthesized a new series of 2-(4-chlorophenyl)-3-{4-[6-(substitutedphenyl)-2-thioxo-1,2,5,6-tetrahydropyrimidin-4-yl]phenyl}-1,3-thiazolidin-4-one derived from 3-{4-[3-(substitutedphenyl)prop-2-enoyl]phenyl}-2-(4-chlorophenyl)-1,3-thiazolidin-4-one and thiourea. The title compounds were characterized by element analysis, IR, NMR and spectral data. All the compounds were tested for their antibacterial and antifungal activities by Cup Borer method. 

Objective: the objective of study was standardizing single Unani herbs used in Polyherbal formulation. In this article, we have provided standardized value of specimen of Nakhood (Cicer arietinum), Baqila (Vicia faba), Turmus (Lupinous albus), Khatmi (Althea officinalis) and Methi (Trigonella foenum). Method: These drugs were assessed on physico-chemical and analytical parameters viz: 1) macroscopic and microscopic features, 2) extractive values 3) moisture contents 4) ash values 5) loss of weight on drying 6) pH of 1% and 10% solution. Results and discussion: Results showed all the drugs involved in study were of standard quality as there moisture content less than 10%, total ash value less than 10%, water-soluble ash values of the individual drugs were in the range of 0.8 to 3% w/w which shows all drugs were of good quality. Acid insoluble ash up to 1% and pH of 1% and 5% of each drug was found to be around 7 with mild basic in nature which is good to neutralize acidic medium produced on scalp because of dandruff. Extraction values done in aqueous medium shows water soluble constituents such as tannins, sugars, plant acids and mucilaginous compounds. Alcohol soluble extraction values shows the presence of tannins, alkaloid and resins similarly ether/ chloroform extraction value show presence of volatile oils, fixed oils and resins. Conclusion: polyherbal formulation is standard quality and its application for desired action can give promising results. 

Wound is an anatomical and functional disruption of the skin which leads to an injury. In response to such injuries, wound healing is a complex process resulting in tissue repair or remodeling. In the present times, there are different types of pharmaceutical products such as synthetic adhesive/ non-adhesive bandages developed for economical, sustainable, stable, and effective delivery system for the treatment of wounds but may lead to side effects. Hence in order to overcome such problems, plant or plant derived products can be used. Historically, plants and plant derived constituents were been extensively utilized for the treatment and management of different types of wounds. The whole study gives precise data of such plants, by making them use in preparation of organic bandages and patches for treatment of wounds. The utilization of these plant derived extract can be more beneficial and effective which can be administered for injuries due to wounds either chronic or acute. Making appropriate use of herbal plants may lower the risk of adverse effects of synthetic forms and may also increase its mechanism of action for efficient tissue remodeling. The compiled data aims to provide the researchers/scientists a directional view in understanding the role and importance of plant-based formulations for the treatment and management of wounds and moving towards natural form of bandages for more efficiency and potency. 

Cinnamomum cassiaBlume(Cinnamon) is a well-known traditional medicine with therapeutic benefits for centuries. The plant Cinnamon cassia Blume is commonly known as Chinese cinnamon. Mostly its bark and leaves are used in medicine. C. cassia is safe when used in small amounts as in foods and medicinal doses. Cinnamomum cassia Blume (Family: Lauraceae) is often used as a substitute for cinnamon.The bark of cassia is coarser and thicker with a more intense aroma than the true cinnamon, C. verum . Around 250 species of this genus are identified around the world. The Chinese cinnamon bark (C. cassia) contains, cinnamon oil, cinnamaldehyde, eugenol,It also contains mucilage, starch & tanninscinnamyl acetate, cinnamic acidphenyl propyl acetate, orthocumaric aldehyde, tannic acid, and starch. Cinnamaldehyde- showed potent anti-bacterial and anti-fungal activities. The whole plant is medicinally important in the Indian traditional system of medicine. In this review, the reported pharmacological activities of C. cassia Blume to cure or prevent several diseases. Different pharmacological activities like anti-inflammatory, antioxidant, hepatoprotective, antihyperlipidemic, antidiabetic, antimicrobial activity activities of C. cassia Blume. The present article describes a detailed review of literature for this plant species including taxonomy pharmacology and photochemistry in an organized way. This review paper will surely serve as an important source for future scientific investigations on this plant.