IAJPR

Indo American Journal of Pharmaceutical Research

ISSN NO.: 2231-6876
NOVEMBER 2020
1

A REVIEW ON IMMUNITY BOOSTER- A HERBAL REMEDY TO FIGHT AGAINST COVID-19

Miss Dube Shubhada Bhausaheb, Deepak S Musmade, Swati. S. Pagar, Divya Kishor Vaykos & Sunanda Bhavrao kharat
Nandkumar Shinde College of Pharmacy, Vaijapur.

This review focused on the use of plant?based foods and herbal pharmaceutical formulation for enhancing the immunity against COVID?19. In humans, corona viruses are causing the common cold and, recently, severe acute respiratory syndrome (SARS) these present a major threat to public health. The novel corona virus has spread rapidly to multiple countries and has been declared a pandemic by the WHO. COVID?19 is usually caused a virus to which most probably the people with low immunity response are being affected. Plant?based foods increased the intestinal beneficial bacteria which are helpful and make up the immune system. By the use of plenty of water, minerals like magnesium and Zinc, micronutrients, herbs, food rich in vitamins C, D and E, and better life style one can promote the health and can overcome this infection. Various studies investigated that a powerful antioxidant glutathione and a bioflavonoid quercitin may prevent various infections including COVID?19. In conclusion, the plant?based foods play a vital role to enhance the immunity of people to control of COVID?1This review focused on the use of plant?based foods and herbal pharmaceutical formulation for enhancing the immunity against COVID?19. In humans, corona viruses are causing the common cold and, recently, severe acute respiratory syndrome (SARS) these present a major threat to public health. The novel corona virus has spread rapidly to multiple countries and has been declared a pandemic by the WHO. COVID?19 is usually caused a virus to which most probably the people with low immunity response are being affected. Plant?based foods increased the intestinal beneficial bacteria which are helpful and make up the immune system. By the use of plenty of water, minerals like magnesium and Zinc, micronutrients, herbs, food rich in vitamins C, D and E, and better life style one can promote the health and can overcome this infection. Various studies investigated that a powerful antioxidant glutathione and a bioflavonoid quercitin may prevent various infections including COVID?19. In conclusion, the plant?based foods play a vital role to enhance the immunity of people to control of COVID?19. 


 


2

REVIEW ON PYRIMIDINE ANALOGS AS POTENTIAL ANTIHYPERLIPIDEMIC AGENTS

Prashant Chavan1, Amitkumar Raval1, Avinash V. Patil2*
1Pacific Academy of Higher Education and Research University, Udaipur, India.
2Smt. S. S. Patil College of Pharmacy, Chopda-425107, District Jalgaon, Maharashtra, India.

Hypercholesterolemia is considered as one of the most important risk factors and thereby a primary therapeutic target. Measurement of serum lipid concentration helps in identifcation of the subject with cardio metabolic abnormalities or risk of cardiovascular diseases. Although, the benefits of lowering cholesterol level has been widely known for the prevention of heart diseases. AcetylCoenzyme A: cholesterol acyltransferase (ACAT) and cholesteryl ester transfer protein (CETP) are the new targets which are directly or indirectly involved in hyperlipidemia. The rising tide of obesity, diabetes and hypertension are collectively attributed to our reluctance to exercise and desire for fast food. Cessation of smoking, control of blood pressure and blood levels of glucose, low density lipoprotein cholesterol (LDLC), as well as elevation of high density lipoprotein cholesterol (HDLC) levels remain the most effective long-term options for controlling atherosclerosis. Raised Cholesterol Situation and trends in india and globally is described. A variety of drugs used in the therapy belong to the classes of fibrates, statins, bile acid sequestrants, niacin derivatives, as well as, some newer drugs like ezetimibe, avasimibe, eflucimibe, lapaquinstat acetate, lomitapide mesylate, etc., are available in the present antihyperlipidemic therapy, but still there are problems associated with most of these currently available lipid lowering drugs. Current new drug discovery efforts to develop new molecules for antihyperlipidemic research involve focussing on various new molecular mechanisms of hyperlipidaemia and thereby several attractive molecular targets involved thereof in this process are being exploited. Peroxisome proliferation activated receptors (PPARs) [agonists of PPARs] is one of the most important target identified as antihyperlipidemic agents. This review deals with many new molecules may offer an insight for developing new leads for antihyperlipidemic therapy to budding researchers in this field. 


 


3

PATIENT MEDICATION COUNSELLING PRACTICE ON DISPENSING OF MEDICINES AND ASSOCIATED FACTORS IN OUTPATIENT PHARMACIES OF BAHIR DAR CITY, NORTHWEST ETHIOPIA

Anteneh Mengist1*, Ruth Wondie2, Abel Lulie2, Hayat Melkamu2, Sefineh Fenta3
1College of Medicine and Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
2College of Medicine and Health Sciences, Gamby Medical and Business College, Bahirdar, Ethiopia.
3College of Medicine and Health Science, Woldia University, Woldia, Ethiopia.

Dispensing drugs with appropriate counseling is a critical part of the drug use process. Proper counseling will result in an improvement in patient compliance and its therapeutic outcome. Regardless of the modern facilities, extensive education, and careful diagnosis, in reality, inappropriate or incorrect dispensing results in all the benefits of the health care system valueless and contributes for the raise of drug resistance to a dangerously high level. Despite this, globally more than half of all medicines are dispensed or sold inappropriately. This study was aimed at assessing patient medication counseling practice on dispensing of medicines and its predictors in outpatient pharmacies of Bahir Dar city, 2020. A cross-sectional study was employed using an observational checklist and interviewer-administered questionnaire to all outpatient pharmacies of Bahir Dar city with considering only one dispenser as a participant from each outpatient pharmacies. The data were analyzed using SPSS version 20.0. Out of 123 dispensers, only 59.3% of them have good patient counseling practice and no one delivers complete medication counseling for the patient in Bahir Dar city outpatient pharmacies. The most frequent drug information give to clients were unit dose (93.5%), frequency of administration (92.7%), and duration of therapy (76.4%). Whereas, drug storage places at home, what patients do if they miss a dose, and not sharing drugs with others were least frequently counseled. Educational qualifications, workload, and years of work experience affect medication counseling practice significantly. Patient medication counseling is still unacceptably low in Bahir Dar city outpatient pharmacies and it was significantly affected by patient load, educational qualification, and work experience. So, to come up with better improvement in patient medication counseling practice these factors need special focus by the concerned bodies.