Deepak Bharadwaj PVP*, Shivaraj Gowda T, Chiranjib B, Narendar D, Saisri K.
Sri krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (mdl),
Dist. Medak, Siddipet. Andhra Pradesh, India.-502277, Email: firstname.lastname@example.org
Human brain is the most evolved complex structure in the body. Various neurodegenartive diseases like alzemiers disease, Dementia, attention deficit, were set as tough challenges in the medical field. The current medical research studies focuses on the potential usage of herbal drugs. The present study was carried out with an interest and contribution for herbal medicines as essential potent drugs. Ervatamia coronaria (Linn) is glabrous, evergreen tree commonly grown in gardens and various parts of the plant were used in the indigenous system of medicine for the treatment of various disorders. To validate the ethnotherapeutic claims of the plant for its use as a brain tonic, the Learning & memory enhancing activity of ethanolic and aqueous extracts of aerial parts of Ervatamia coronaria was evaluated by Elevated plus maze apparatus in mice. The effect of transfer latency (TL) due to extracts (ethanolic & aqueous at 200,400 mg/kg) and standard drug (Piracetam 200mg/kg) were compared to that of control and negative control (Diazepam 5mg/kg). The effect of herbal extracts was evaluated on elevated plus maze apparatus in Diazepam induced amnesia in mice. It is observed that the ethanolic & aqueous extracts at various doses(200 mg/kg) has significantly reduced the transfer latency in mice compared to control and negative control groups in a dose dependent manner and results were comparable to the standard Piracetam treated group. From the results obtained, it is evident that the traditional herbal extracts have significant learning and memory enhancing property.