The present study is of formulation and evaluation of Atazanavir co-crystals to improve drug oral bioavailability. Atazanavir co crystals were prepared by sovent evaporation technique using Oxalic acid, succinic acid, saccharin, were as co crystal formers, various formulations were prepared these polymers. The Atazanavir co-crystals were characterized with respect to IR, DSC, XRD, angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio, and stability studies and all the results indicated that the co-crystals were having good flow nature. Conclusion: By the in vitro dissolution studies it was concluded that the formulation prepared with oxalic acid in the concentration of 200mg (F4) was showing better result 98.97% drug release. 

Background: Breast cancer is the most common invasive cancer in women, and the second main cause of cancer death in women, after lung cancer. Traditional medicine has been used to treat various types of cancer and these are found to be effective with minimal or no side effects. Objective: To evaluate the anticancer activity of polyherbal formulations (PGM-12 and PGM-13), Doxorubicin and combination of both in DMBA induced breast cancer in rats. Methodology: The mammary gland tumor in rats was induced by a single dose of 65mg/kg p.o of DMBA. After development of visible tumors, the rats were administered with polyherbal formulations (200mg/kg/p.o/day of PGM-12 and PGM-13), Doxorubicin (2.5mg/kg/i.p/ week) and combination of both polyherbal formulations and Doxorubicin for a period of 8 weeks. The anticancer activity of the polyherbal formulation was assessed by recording difference in tumor volume, tumor weight and histopathological examination of tumors after the study. To evaluate nephroprotective effect of treatment renal functional parameters and renal antioxidant enzymes were also measured. Results: The treatment with polyherbal formulations, Doxorubicin and combination showed a significant decrease in the tumor size and tumor weight compared to positive control. The polyherbal formulations has improved the renal function parameters and increased the antioxidant enzymes level significantly compared to positive control and doxorubicin group. Conclusion The findings of our study revealed that the combination of polyherbal formulation and doxorubicin exerted synergistic effect by inhibiting the tumor growth. The combination protected the kidney from the nephrotoxic effect of Doxorubicin in DMBA-induced mammary tumor in rats. 

Drug delivery systems are designed in order to achieve maximum therapeutic efficacy of the drugs while reducing their toxicity. The modern drug dosage forms have been the result of a long scientific research in the field. Using sophisticated technologies and exploring novel excipients with outstanding physicochemical characteristics have led to the development of modern novel drug delivery systems from simple pills and mixtures. Emulsions are biphasic systems having one phase dispersed in the other phase in the form of droplets ranging in diameter from 0.1 to 100 ?m. Thermodynamically, they are unstable in nature, but can be made stable with the applications of emulsifiers or emulgents. , the surfactants used as emulsifiers are termed as interphaseor intermediate The “Nanoemulsion” term is used for thermodynamically stable isotropically clear dispersion of two immiscible liquids like water and oil stabilized through the surfactant molecules interfacial film. They are novel drug delivery systems in which oil is emulsified in an aqueous system in the form of droplets with a mean diameter 100-500 nm. Nanoemulsions have found wide spread applications as drug delivery vehicles due to some of their distinguished characteristics. There is a growing interest for using of Nano/sub-micron particles in the technology of pharmaceutical, cosmetic and also food industries. Nanoemulsions are also preferred due to their administration through multiple routes. They are used for efficient drug delivery through skin because of the large surface area they provide for the drug penetration. Moreover, they have been nontoxic and nonirritant to the mucous membrane and skin tissues. Their fluidity and avoidance of thickeners in theirformulations make them transparentwithaestheticphysicalappearance. In this paper, a comprehensive review is presented to give basic ideas about properties of Nano emulsions, their preparation methods, and evaluations. 

Buccal drug delivery has become the most important route of administration of drug due to unwilling of oral administration of solid preparations by both pediatric and geriatric patients. This has led to development of alternate route of administration like film drug delivery system. Fast dissolving drug delivery systems were developed in 1970s as an alternative to syrups, capsules and tablets for pediatric and geriatric patients. They have been accepted easily as new drug delivery system because of easy administration, rapid drug absorption, better patient compliance and good bioavailability. 

In recent years many new pharmaceuticals sustain release formulation are developed like liposomes, niosomes, microspheres, nanaospheres etc. among them microsponges is one of the novel formulations. Physically microsponges are sponge like submicron structure with porous nature. As the formulation is porous nature with inter particular space, more amount of drug entrapment is possible and sustain release of drug can be achieved. Many microsponge preparations are limited to topical applications. Recent studies revels that this formulation can explore to other areas like gastro retentive systems, colon targeting, cosmetics, ophthalmic preparations etc. In the current review discuss about various aspects of microsponges like their preparation, characterization, safety aspects, recent developments and the future development aspects. 

Melioidosis is a communicable disease caused by Burkholderia Pseudomallei, a gram negative bacteria. Depending on the type of organism, the symptoms may also differ. Pulmonary, bloodstream, local and disseminated infections are the forms of melioidosis. In this case, the patient was admitted with fever with chill and rigors, and breathing difficulties for past few days. Bronchoalveolar lavage culture and sensitivity test of the patient showed growth of “Burkholderia Pseudomallei”. Early diagnosis and appropriate antibiotic treatment improved the patient condition. The standardized treatments include intravenous Ceftazidime or meropenem, followed by Sulphamethoxazole/Trimethoprim as eradication therapy.Melioidosis is a communicable disease caused by Burkholderia Pseudomallei, a gram negative bacteria. Depending on the type of organism, the symptoms may also differ. Pulmonary, bloodstream, local and disseminated infections are the forms of melioidosis. In this case, the patient was admitted with fever with chill and rigors, and breathing difficulties for past few days. Bronchoalveolar lavage culture and sensitivity test of the patient showed growth of “Burkholderia Pseudomallei”. Early diagnosis and appropriate antibiotic treatment improved the patient condition. The standardized treatments include intravenous Ceftazidime or meropenem, followed by Sulphamethoxazole/Trimethoprim as eradication therapy.