G.V.Radha, CH.Veerendranath Chowdary
GITAM Institute of pharmacy, GITAM University, Rushikonda, Visakhapatnam, Andhra Pradesh State, India.
Proniosomes are converted into niosomes on hydration, the reason for adopting Proniosomal technology that they exists as a liquid crystalline state, this state of existence is much stable than normal niosomes. This research mainly emphasizes on formulating Proniosomal gels with span surfactants, cholesterol, soya lecithin and alcohol as aqueous phase. Ornidazole drug is chosen as an active ingredient in preparation of Proniosomal gels, these are prepared by coacervation phase separation method and the prepared formulations characterized for FTIR studies, Encapsulation efficiency, size distribution and In vitro release studies were carried. FTIR studies were carried and showed that there was no interaction between API and used excipient. The encapsulation efficiency of Proniosomal formulations are in the range of 38% to 78%. Morphological size and shape of the vesicles are characterized by using optical microscopy and scanning electron microscopy, particles are found to be spherical, size of the particles are in the range of 3.29μm to 30μm and permeation studies showed good control release for prolonged period of time. Span20 Non lecithin formulation showed highest amount of drug release of 88% in 24 hours. In vitro rat skin permeation studies proved that good amount of drug is permeated than the marketed formulation. The results suggest that Ornidazole proniosome formulations can be used for Topical drug delivery system for the treatment of skin infections.