A REVIEW ON CNS TARGETING
Antony Deva Punitha, Anand Kumar Srivastava*
*Deparment of Pharmaceutics, Indian Institute of Technology (IIT-BHU), Varanasi – 221 005, India.
Still, CNS targeting is at its infancy state; and CNS-acting candidates have the poorest success rate. In this context, this article discusses the various approaches taken for CNS targeting with their limitations. The list of approaches employed for CNS targeting starts from pro-drug, lipid mediated transport, chemical delivery system viz. dihydropyridine- pyridinium type redox delivery system to neurosurgical invasive brain delivery viz. direct intra-cerebroventicular injection. However, whether we have been successful in CNS targeting with the above mentioned strategies is a question of note. On the other hand, it discusses the presence of various specialized transport mechanisms on brain microvessel endothelial cells (BMEC) that forms the BBB. This article, further, throws light on Carrier mediated transportation (CMT) and CNS transportation of therapeutics achieved through CMT strategies.