Aristolochia Rotunda Linn has been known as zarawand-mudahraj in Unani Medicine. It belongs to the family aristolochiaceae and commonly known as the Smearwort, snake root, European birthwort. It has been used in Unani system of medicine for various properties such as immunomodulatory, anti-inflammatory, anti-neoplastic, anti-bacterial, anti-oxidant, hepatoprotective activity. In Unani system of medicine for various therapeutic actions such as musakkin-i-alam, muh ? allil awr?m, mufattih ? -i-sudad, mudir-i- h?ayd?, mudir-i- baul wa h?ayd?, muqawwi-e-bah, muqaww?, muharrik, muqawwi-i- asab, muhallil, mula??if, munaffith -i- balgham, mushil-i-balgham, muqateh wa mukhrij-i-balgham, munaaqi e dimagh,munaqqie meda munaqqie qabatur ria, mulayyin, q?til-i- kirme shikam, mudammil qur??h, d?fi?-i-zaher or tiry?q-i-sumoom, j?li, jazib since centuries. In Unani literature, Roots are of two type’s zarawand taveel and zarawand mudharaj based on geographical distribution, some Unani scholars depicted the varieties of zarawand mudharaj viz. zarawand mudharaj shami, zarawand mudharaj rumi and zarawand mudharaj maghribi. The present article describes a detailed review of literature of this plant species including taxonomy, pharmacology, Phyto Chemical Constituents and pharmacological activities in an organized way. This review paper will surely serve as an important source for future scientific investigations on this plant. 

Coumarinic compounds are a class of lactones, structurally constructed with fusion of a benzene ring and ?-pyrone ring. Previous research studies have demonstrated that coumarin and its derivatives exhibit many pharmacological properties such as antitumor, antibacterial, antifungal, anticoagulant, antioxidant, anti- inflammatory and many others. In this study we had dealt with its antimicrobial activity followed by pH analysis. The aims of this study are to prepare and identify the crude coumarin extracted from cassia cinnamon and to study its antimicrobial activity. The antimicrobial activity of extracted crude coumarin from cinnamon sample was tested for antimicrobial pattern against gram positive, gram negative bacteria and fungi. The study of Minimum inhibitory concentration was performed by disc diffusion method. The highest activity in terms of zone of inhibition (22.32mm) was observed against gram negative bacteria E.coli(shown in fig.6).Other gram positive bacteria staphylococcus aureus was also found susceptible to ethanolic extract and inhibition zone was noted as a 12.61mm (shown in fig.7). C. albicans fungi was also found susceptible to ethanolic extract and inhibitory zone was recorded Ambiguously in a wide range between 5-19 mm. However, there was no zone of inhibition found for aqueous extract form. In comparison with broad spectrum antimicrobial activity, maximum antibacterial activity was shown by E.coli followed S. aureus. The pH analysis was performed & it was found to be non-reactive with different acid & bases (Strong & Weak), So it cannot be used for titrimetric analysis although it has pigment but it can be effectively used as one of the active ingredient on skin without concerning about the change in pH of formulation. 

Medicinal plants have been known from pre-historic times and these are the backbone of traditional medicines. JSSAC has brought up a comprehensive herbal garden which constitutes more than 300 medicinal plants. In the present paper around 100 medicinal plants have been identified and distinguished based on part used to cure different aliments and also included Botanical name, family, part used, habit and medicinal uses of the plants. 

A large group of pectinase enzymes cause the breakdown of pectin polysaccharides from plant tissues and form a simpler molecule known as galacturonic acid, which is also widely used to increase yields and clarity of fruit juices. In this study, two bacterial strains have been isolated from rotten fruit (orange) using serial dilutions of 10-2 and 10-4 on 2% pectin agar media, as two bacterial strains have been identified. The pectinolytic activity was determined using pectin containing minimal essential medium and carrot waste medium (CWM). The plate assay was used to determine the temperature of 30-200C. The highest pectinolytic zone was found to be 8 mm, which was Staphylococcus aureus. The results indicate an efficient and promising producer of pectinase. also shows more enzyme activity, for the improvement of quality and clearance of fruit juice (Orange).

The current work describes development and validation of a simple, accurate and precise stability-indicating high performance thin layer chromatographic (HPTLC) method for determination of Apremilast as bulk drug and in tablet dosage form. As stability testing is major step in the development of new drug as well as formulation, stress degradation studies were carried out according to ICH guidelines. Apremilast was found susceptible to all the analyzed stress conditions except photolysis. The separation was performed on pre-coated silica gel 60 F254 plates (10 cm×10 cm) utilizing Toluene: Ethyl acetate (5: 5, v/v) as mobile phase with densitometric scanning at 230 nm. The retention factor was found to be 0.53 ± 0.02.Results were found to be linear in the range 100-600 ng band-1. The developed method has been effectively applied for the drug estimation in tablet dosage form. The % drug content was found to be 100.03. The method was found to be precise as % R.S.D. values were less than 2. The developed method is stability indicating and can be successfully employed for quantification of drug in tablet dosage form. The results clearly indicated that there was no interference of the related substance for Apremilast which demonstrated that the developed method was stability-indicating and can be used for drug stability studies and quality control monitoring of Apremilast. 

The antibacterial target, enoyl-acyl carrier protein (ACP) reductase, is a homotetrameric enzyme that catalyzes the last reductive step of fatty acid biosynthesis. In the present paper, Surflex docking has been carried out on a series (10 compounds) of enoyl ACP reductase inhibitors, using the SYBYL-X 2.0 package (Tripos Inc., St. Louis, USA). Surflex-docking studies revealed that the carbonyl group and pyrazole ring were significant for binding to the receptor, and it is also found that the pattern of binding of tested compounds is same as that of the 4TZK ligand, this in turn helped in understanding of specific activity of compounds.