WONDERS OF VERSATILE SPHERULITES
The objective of this study is to assess the various applications of spherulites that are muticoncentric, multilamellar microvesicles possessing morphology similar to an onion.Simultaneous encapsulation of both hydrophilic and lipophilic active ingredients is possible as they consist of concentric bilayers of amphiphiles alternating with layers of aqueous medium.Small and long circulating fullrene induced polymer spherulites is used for controlled delivery.Around 80% oligonucleotides were encapsulated in spherulites and were successfully delivered.Thus it proved to be a promising oligonucleotide carrier. Antisense oligonucleotides have been used to inhibit thousands of genes by RNAs H dependent mechanism. Currently antisense drug formivirsen is used to treat CMV retinitis. Spherulites are also found to be a promising vehicle for delivering the actives to the skin and hair from shampoos as they are stable when included in rinse off products. It may prove to be highly effective in cleansing personal care products in coming years.Spherulites have found to be used as parenteral drug sequestering agents in order to treat drug overdose and chemical poisoning. Thus spherulite technology will help reduce the adverse of overdosed drugs by altering their pharmacokinetics and biodistribution.Innumerable applications developed interest to even discover more on spherulites. Some of its most promising applications are highlighted in this study.