The Juglans regia, Persian walnut, English walnut, especially in Great Britain, common Walnut, or especially in the US, California walnut, is an Old World walnut tree species Native to the region stretching from the Balkans eastward to the Himalayas and southwest China. The largest forests are in Kyrgyzstan, where trees occur in extensive. The walnut tree has a long history of medicinal use, being used in folk medicine to treat a Wide range of complaints. The leaves are alterative, anti-helmintic, anti-inflammatory, Astringent and depurative. They are used internally for the treatment of constipation, chronic coughs, asthma, Diarrhoea, dyspepsia etc. The leaves are also used to treat skin ailments and purify the blood. AIM: The aim of the present study is to formulate and evaluate cleansing cream by using Walnut shell powder prepared by using bees wax-borax type/emulsified type method. METHOD: In our present study we formulated 3 different formulations F1, F2, F3 by incorporating different concentrations of liquid paraffin and Bees wax and evaluated by using various parameter such as physical appearance , viscosity, pH, phase separation, moisture absorption studies, test for microbial growth, Spread ability, Stability studies, Irritability, wash ability, and got fruitful results with all the tests. RESULTS: Among the three formulations (F1, F2, and F3), the formulation F2 was having characteristic Odour, light brown in color, non-irritant to the skin and quite elegant. Also the formulations F1 and F3showed no redness or edema or erythema and irritation during irritancy studies. CONCLUSION: The stable formulations were safe and skin irritations and allergic sensitizations were scarce. All the formulations passed the microbial limit test which included some parameters like total bacterial count and fungal count, pathogens like E.Coli, Bacillus were also absent. 

Objective: With the highest cancer related mortality and morbidity, lung cancer has become a predominant problem world-wide. The antitumor property of vitamin C (VC) has already been demonstrated. However, the precise mechanism and the targets of VC against lung cancer are yet to be discovered. This study is conducted to identify potential targets and underlying mechanisms of VC against lung cancer by bioinformatics analysis of network pharmacology and molecular docking. Methodology: Targets of VC and lung cancer were obtained from various data bases. From the 142 pharmacological targets of VC, 136 overlapping targets with lung cancer were mapped. The 10 potential core targets of VC were identified from mapped proteins. These 10 core targets are subjected to Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes pathway enrichment analysis. The top 20 biological processes, molecular functions, cellular components and pathways were presented. Results: EGFR, ADRA2C, CHRM2, CCR5, MAPK1, BDKRB2, DRD2, AGTR2, ADRA2A and ADRA2B were found to be the key targets involved. Molecular docking studies revealed that VC has highest binding affinity to B2 bradykinin receptor (BDKRB2). The mechanism of VC in lung cancer may be associated with regulation of catecholamine release by inhibiting BDKRB2 receptor. Conclusion: VC can suppress tumour development and progression in lung cancer. Further pre-clinical studies are required for VC before it is used as a therapeutic agent in lung cancer.Objective: With the highest cancer related mortality and morbidity, lung cancer has become a predominant problem world-wide. The antitumor property of vitamin C (VC) has already been demonstrated. However, the precise mechanism and the targets of VC against lung cancer are yet to be discovered. This study is conducted to identify potential targets and underlying mechanisms of VC against lung cancer by bioinformatics analysis of network pharmacology and molecular docking. Methodology: Targets of VC and lung cancer were obtained from various data bases. From the 142 pharmacological targets of VC, 136 overlapping targets with lung cancer were mapped. The 10 potential core targets of VC were identified from mapped proteins. These 10 core targets are subjected to Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes pathway enrichment analysis. The top 20 biological processes, molecular functions, cellular components and pathways were presented. Results: EGFR, ADRA2C, CHRM2, CCR5, MAPK1, BDKRB2, DRD2, AGTR2, ADRA2A and ADRA2B were found to be the key targets involved. Molecular docking studies revealed that VC has highest binding affinity to B2 bradykinin receptor (BDKRB2). The mechanism of VC in lung cancer may be associated with regulation of catecholamine release by inhibiting BDKRB2 receptor. Conclusion: VC can suppress tumour development and progression in lung cancer. Further pre-clinical studies are required for VC before it is used as a therapeutic agent in lung cancer. 

Commercially high stocking density of culture practice, the feeding has the significant contribution for fast growth and high yields. The aqua feed is potentiated with many ingredients in highly balanced nutritious components for enhancing the digestive mechanisms in fish and shrimp body. Spirulina has been shown to enhance immune function, reproduction, increase growth and good health. The present investigation has been conducted to understand the effect of spirulina as a feed supplement on health and survival of Macrobrachium lamarrei lamarrei for a period of 90 days. Highest values for health and survival gain in the prawns were observed in prawns fed with 5% Spirulina feed which was recorded to be 94% in case of survival rate and good health. Hence coming to conclusion that using Spirulina in the prawns can improve its health and survival ability.