Objectives: The objectives of the study were to screen the patients for MetSusing NCEPATP-III criteria, to predict the prevalence of CVD risk using FRS and to find out various risk factors associated with CVD. Methodology: Across sectional study was conducted for a period of 6 months. The ethical clearance was obtained from the institutional ethical committee of Bapuji Pharmacy College, Davangere. The estimated sample size was 278. Patients were screened for MetS andCVD risk assessment was done using non – laboratory - based FRS. Categorical data were analyzed using Chi-square test. Quantitative variables were analyzed using unpaired t-test and one way ANOVA. Results: Out of 278 participants, 71.9% had MetSand 28.05% did not have MetS. The participants with three MetScomponents had the highest prevalence of high CVD risk. Using multiple logistic regression, the significant predictors of CVD risk by FRS were male gender (OR=1.00), age 51–70 years (OR=1.13), BMI between 25–29.9 kg/m2 (OR=1.083 for high and OR=1.086 for moderate CVD risk), SBP between140–150 mm Hg (OR=1.028), and FBS 126mg/dl (OR=1.00). Conclusion: Participants with three MetS risk factors had the highest prevalence of high CVD risk Therefore, awareness about the risk factors associated with MetS and the necessity for managing proper dietary pattern and its associated cardiovascular risk.

Drug resistance is a serious and expanding threat to global public health, and it will take continuous and coordinated efforts to develop the novel range of antibiotics to battle against infectious diseases to address this problem. Many studies shown that the aniline and carbonyl compound derivatives have numerous biological and anti-bacterial activity. The purpose of this study was to create 2,3-Dichloroaniline derivatives and characterization of synthesized Schiff bases.1-H NMR and IR spectroscopic studies were used to assess the chemical structure of synthesized Schiff base. Also, it was determined whether the synthesized derivatives had antibacterial activity against Escherichia coli or Staphylococcus aureus. According to the findings, synthesized Schiff bases prevent both Escherichia coli and Staphylococcus aureus from growing. In closing, it's critical to note that the reagents utilized in this study are affordable and don't need additional handling instructions. All the synthesized Schiff bases shown satisfactory result in characterization and shown good zone of inhibition.

Lyophilization (also known as freeze-drying) has been considered as a good technique for improving the long-term stability of nanomedicines. Nanomedicines have found increasing applications in the targeted drug release or controlled drug release, and the development of Nanomedicines as potential candidates mainly aims towards harvesting the sufficiently small size of particle for proper administration, for preserving the drug potency significantly for a long time, and for restoring the bioactivity upon a quick re-dispersion. However, the poor stability in an aqueous medium of these systems forms a real barrier against the clinical use of nanomedicines. Most of the literature reflecting lyophilization technology for processing the nanomaterials falls under medical as well as pharmaceutical research, and this is perhaps due to the natural link existing between the lyophilization and the pharmaceutical development. The lyophilization of nanomedicines, when fully controlled could really revolutionize their use in the medical field thereby ensuring the stability of nanomedicines.This article mainly focuses on recent advances in lyophilization of nanomedicines. 

Herbal formulations always have activity and comparatively lesser or no side effects with synthetic. The growth activity in a concentration range for 1-10% separately. Based on these results mixture of crude drugs fruits of Embelica officinalis, flowers of Hibiscus rosasinensis, leaves of ocimum sanctum, azadirecta indica and seeds of Trigonella foenumgraecum were prepared in the form of herbal hair oil by boiling cloth method and were tested for hair growth activity, refractive index, acid value, saponification value. It holds the promise of potent herbal alternative for synthetic hair oils. Excellent results of hair growth were seen in formulation prepared by boiling method of oils preparation technique. The Herbal cosmetics are nowadays widely used because of fewer side effects with better safety and security .The present work was aimed to formulate polyherbal hair oil for general purpose using various Herbs. Herbal hair oil was prepared from the hair growth. The Formulation were also subjected to chemical test determination. To determine the presence of active constituent in the drug .Excellent result of hair growth were seen in formulation. 

The novel series of pyrrolyl pyrimidine derivatives were synthesized and molecular docking studies were carried out further few compounds evaluated for anticonvulsant activity against MES and PTZ induced convulsions. Purity of the newly synthesized compounds confirmed by using TLC and structures were confirmed by using IR, NMR, ¹³C and Mass spectra. In present work 4-Pyrrole-1-yl acetophenone (1) is refluxed with appropriate benzaldehyde (2) in 40% NaOH for 3 h to form substituted chalcone derivatives (3a-j) which is further stirred with urea in ethanolic sodium hydroxide solution for 3 hr to form titled compounds (4-(1H pyrrol-1yl) phenyl (2-hydroxy-6- substituted phenyl) 1, 2 dihydro pyrimidine-5yl) methanone (4a-j). Docking study was performed by Surflex-Dock program that is interfaced with Sybyl-X 2.0. Compounds 4m and 4n showed excellent consensus scoreat 7.21 &5.92 respectively. Docking study reveals that all the compounds have showed very good docking score against the enzyme. The few newly synthesized compounds were screened for their anticonvulsant activity. Compounds 4d (13.49±0.80) and compound 4e (9.64±0.48) showed significantly decrease in hind limb extension against MES induced convulsions. Compound 4b (136.5 ± 2.04) and 4e (126.7 ± 2.29) showed protection against PTZ induced convulsions. Simultaneously activity is compared with control and standard group. The newly synthesized novel series of pyrrolyl pyrimidine derivatives may be developed into potential class of anticonvulsant agents in future.