Pankaj Sharma*, Ashish Dixit, Dheerendra Rathore, Yogendra Rajpoot, Ramakant Joshi, Kuldeep Singh
Shri Ramnath Singh Institute of Pharmaceutical Science & Technology, Gwalior.
The main objective of the study is to formulate and evaluate orodispersible tablets of Primaquine with synthetic superdisintegrants. Various formulations of Primaquine were prepared by direct compression method using different ratios of synthetic superdisintegrants (sodium starch glycolate, croscarmellose sodium and crospovidone) at the concentrations ranging from 3%-12%. The drug and excipients compatibility study was performed by IR to study the interaction between drug and excipients. The blend of all formulations were evaluated for various pre-compressional parameters such as angle of repose, bulk, tapped densities, compressibility index, Hausner’s ratio and the prepared tablets were evaluated for various parameters like weight variation, thickness, hardness, friability, wetting time, water absorption ratio, disintegration time, content uniformity and in vitro drug release. Formulations with treated agar have shown promising results compared to other formulations with semisynthetic superdisintegrants. The optimized formulation was subjected to stability studies for three months as per ICH guidelines. Disintegration times of formulations containing treated agar were found to be in the range 30-27sec and 95-100% drug release was observed in 5 min. The optimized formulation was found to be stable with insignificant change in the hardness, disintegration time, drug content and in vitro drug release. In conclusion, it can be stated that the objective of the study has been achieved. From the above study, F6 formulation was concluded as an optimized formulation due to its less disintegration time.