A Series of Bioactive compounds, 4,6-diphenyl pyridine-3(2H)-one(1a), 6-(4-cholo phenyl)-4-phenylpyridne-3(2H)-one(1b), 6-(4-amino phenyl)-4-phenyl pyridine-3(2H)-one(2a), 6-(4-nitro phenyl)-4-phenyl pyridine -3(2H)-one(2b), 6-(4-methoxy phenyl)-4-phenylpyridine-3(2H)-one(3a), were Synthesized according to the Literature methods. The Synthesized compounds were characterized by NMR, IR & Mass Spectroscopy. 

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline. This review examines the potential neuroprotective roles of neurosteroids like allopregnanolone (AlloP) and 24(S)-hydroxycholesterol (24(S)-HC) in AD. Multiple preclinical studies in rodent models demonstrate the ability of AlloP to promote neurogenesis, myelination, and anti-inflammatory effects via GABA receptor modulation. Enhanced AlloP levels reduced amyloid-beta pathology in an AD mouse model. The enzyme CYP46A1 converts cholesterol to 24(S)-HC which can exit the brain. CYP46A1 upregulation appears neuroprotective in some AD models through improved cholesterol homeostasis. Analysis of human AD patient brain tissues reveals reduced AlloP levels correlating with disease progression. Overall, these neurosteroids show promise as novel AD therapeutics by targeting pathogenic mechanisms like neurodegeneration, neuro inflammation and amyloid-beta aggregation. Further research especially large-scale clinical trials are warranted to strengthen the preclinical evidence. In conclusion, neurosteroids augmentation could provide a new avenue for prevention and symptomatic management in AD. In summary, this draft abstract highlights the key findings from the research review on neuroprotective roles of allopregnanolone and 24(S)-hydroxycholesterol in Alzheimer's disease models and patients. It summarizes the major outcomes demonstrating their abilities to reduce neurodegeneration, inflammation and amyloid-beta pathology. The abstract concludes that these neurosteroids represent promising novel therapeutic candidates for Alzheimer's disease worthy of further clinical investigation. Please let me know if you would like me to modify or expand the abstract in any way. 

Most of the people consume cookies during their breakfast, snacks and leisure time to regulate their hunger and get some energy, in market there are varieties of cookies which are available, and the main components are refined flour, sugar and butter. Hence, are generally avoided by obese and diabetic patients as they lead to high sugar level in blood. Therefore, in this recent investigation, we have formulated Poly herbal cookies using oats, wheat flour and different Ayurveda herb. Diverse varieties were formulated using different plant to find out the best composition for cookies on the basis of palatability. After selection, cookies were formulated for the physio chemical, sensory and their nutritional analysis. Sensory analysis was evaluated based on organoleptic characteristics: color, taste, aroma and overall acceptability on the basis of 9 – pointhedonic scale. Physiochemical evaluation including: total ash value, total moisture content total water and alcoholic extraction, total moisture content. On the basis of its nutritional value comparison, it was found that the protein content is higher in our formulation than the other marketed preparation. 

Envenomation by snakes is a significant socio-medical issue. More than 100,000 people die from snake bites each year, which affect over 2.5 million people. Although snake bruises may be fatal, snake venom is a naturally occurring an organic resource that includes a number of elements that may have medicinal utility. Ayurveda, homoeopathy, and folk medicine all use venom to treat a variety of pathophysiological diseases. With the development of biotechnology, the effectiveness of such treatments has been demonstrated by isolating the medicinal characteristics of venom components. This review will concentrate on specific elements of snake venom and how they are used to treat illness and prevent it. Numerous helpful substances have been discovered, most notably the disintegrins (eptifibatide and tirofiban), which have been demonstrated to be potent anti-platelet aggregation both in vitro and in vivo. While the original native compounds found in snake venom are typically unsuitable for therapeutic use, advances in pharmaceutical R & D made it possible to use the proteins found in snake venom as therapeutics for a variety of disorders based on the knowledge of their structural and functional properties. With their unique combination of ingredients, snake venoms hold enormous promise as cures for human illnesses. For thousands of years, nature has served as a source for therapeutic substances, and snake venoms are a particularly rich supply of bioactive compounds, including peptides, proteins, and enzymes with significant pharmacological functions. Furthermore, traditional Chinese medicine has made extensive use of the blood and bile duct of snakes. Protein fold structures have made it possible to create a wealth of peptides that interact specifically and very affinitively with human protein. This will aid in understanding the effects of each interaction and pave the way for the creation of potent medications that are specifically targeted at particular protein activities. 

Over-the-counter medicines play a key role in public health, as they provide readily available and convenient options for self-medication. This review examines the safety, accessibility, and regulatory aspects of over-the-counter medicines. Safety considerations include the potential risks and benefits of self-medication, including side effects, interactions with other medications, and the importance of appropriate use. Accessibility examines the widespread availability of over-the-counter medicines, enabling people to manage minor health problems independently. Regulatory aspects include the regulatory framework for the manufacture, distribution and sale of over-the-counter medicines and emphasize the need for strong regulatory oversight to ensure product efficacy and consumer protection. A thorough understanding of these aspects is important for health care providers, regulators, and consumers to make informed decisions, promote responsible use of over-the-counter medications, and promote overall public health. 

Nutraceuticals are products that have both nutritional benefits and therapeutic effects, making them highly valuable in maintaining optimal health. They play a significant role in human healthcare and have become increasingly popular in promoting health and disease reduction. They are also used as a support therapy for the prevention and treatment of various diseases, including reducing the side effects of cancer chemotherapy and radiotherapy. This review article discusses the various drug-nutraceutical interactions and elaborates on several patents on nutraceuticals in agricultural applications and various diseases, confirming the exponential growth of the nutraceuticals market value. To overcome the challenges involved in the formulation of nutraceuticals, diverse novel nano-formulation approaches have been developed. These approaches have led to micronized dietary products and other nutraceutical supplements with improved health benefits. It is important to have prior information on the various interactions between nutraceuticals and drugs to prevent any deleterious effects of nutraceutical products. The latest clinical studies on nutraceuticals that show the therapeutic action of nutraceutical bioactive molecules on various diseases have also been discussed in this review article.

The sustainability of 3D printing for industrial usage is attributed to its characteristics, which include minimal material waste, ease of manufacture, low human participation, minimal post-processing, and energy efficiency. Various 3D printing techniques are covered in the study, along with their benefits and cons. All the materials that work with different kinds of 3D printing processes are explained in detail. Additionally, the document lists the several fields in which each kind of method finds application. Industry 4.0 has also been covered in detail in this section. According to the literature review, even though 3D printing has advanced significantly, there are still problems that need to be solved, like material incompatibility and material costs. Technologies used in Additive Manufacturing fall under the broad category of 3D printing. Each of them constructs objects in successive layers, with an average thickness of 0.1 mm. To put it simply, 3D printers fall into four categories. First, we have printers that extrude a material that is either molten or semi-liquid. Additionally, printers that firm photocurable resin exist. Thirdly, powder granules can be fused or bound together using printers. Last but not least, there are printers that fuse together sliced sheets of metal, plastic, or paper. It is now widely known that 3D printing has the potential to produce incredibly exciting and remarkable outcomes in the healthcare industry. The idea of using 3D printing in medicine is not new. In the late 1980s, work on the first commercial bioprinters and 3D printers got underway. But only because of increased funding and technological advancements over the past few years have the capabilities, applications, and demand increased.