Indo American Journal of Pharmaceutical Research

ISSN NO.: 2231-6876


Shankrayya .M*, Tejashwini. J M, Chaithra .D, Venkatesh .J. S.
Dept of Pharmaceutics, S.C.S College of Pharmacy Harapanahalli.

In this study, lafutidine effervescent tablets were developed to replace traditional lafutidine tablets in the treatment of gastric and duodenal ulcers, where rapid start of action is advantageous in controlling gastric and duodenal ulcers and aids in bioavailability. Use various acid sources, such as citric acid (F1-F3), tartaric acid (F4-F6), fumaric acid (F7-F9), and carbonate sources (such as sodium bicarbonate) to prepare effervescent tablets using direct compression. The produced tablets are tested for properties after compression, like hardness, friability, thickness, weight change, drug content, CO2 content, in vitro disintegration time and stability tests. Drug excipient compatibility was investigated using FT-IR and DSC in the preformulation research, suggesting that medicines, acids, bases, and other excipients are compatible. Pre-compressional parameter values were within specified limits, indicating satisfactory free-flowing properties. Except for formulations F1-F3, all post-compressional parameters were tested, and the findings were within acceptable ranges. F11 had the fastest effervescence and disintegration of all the formulations. The produced lafutidine effervescent tablets were stable and kept their medicinal characteristics for 3 months, according to stability testing of the optimised formulation F11. According to the findings of this study, lafutidine effervescent tablets are a viable formulation for the treatment of ulcers. 




Kundap S., Karpe M., Kadam V.
Bharati Vidyapeeth’s College of Pharmacy, Belapur CBD, Navi Mumbai, 400614,

This article intends to provide information on pharmaceutical robots used in industry, as well as to gather and analyse data from previous years relating to the deployment of industrial robots in the market and their impact on worker employment or jobs. Cartesian, SCARA, and articulated robots are the three most prevalent types of industrial robots. These robots can be used in sterile production, laboratories, packaging, 3D printing, and a variety of other pharmaceutical applications. Only a few micro and nanoscale robots are available for drug delivery. As a result, the use of robots has increased. A market analysis of robots as well as a research of the robotic performance to price ratio was conducted. Based on the research, Asia is the world's largest industrial robot market, with an annual installation rate of 13% from 2014 to 2019. According to the performance to price ratio, quality adjusted robot prices were about one-fifth of what they were in 1990 by 2005. This accounted for 15% of overall productivity growth. According to the study, the number of installations is growing year after year, and many companies are contemplating pharmaceutical robots because of their numerous pharmaceutical applications, benefits, flexibility, and capacity to securely collaborate with people. It is expected that in the near future, robotics will play an important role in the pharmaceutical industry. 




Maruthi N*, T S Nagaraja, Uma M, Abdul Munaf S, Arun K A, Abdul Jaseem P T, Akarsh M Shaju
Department of Pharmaceutics, SJM College of Pharmacy, Chitradurga-577502 Karnataka, India.

Herbal cosmetic are the preparation which are used to beautify and enhance the human appearances. The aim of present work is to formulate, evaluate and characterization of Curcumin, Ashwagandha and Neem containing Herbal cold cream. The Curcumin, Ashwagandha and Neem containing Herbal cold cream is prepared by water in oil method by using suitable base for the purpose of nourishing and moisturizing the skin. The herbal extract containing cold cream gives cooling and soothing effect due to slow evaporation of water present in emulsion. The prepared herbal cold creams are characterized for production yields, DSC and SEM. The production yields of formulations were from 78.4% to 87.5%. DSC studies are revealed that the drug and base are compatible with each other during preparation. The changes in physical properties of the formulated creams were not observed. The formulated cream shows good consistency and spreadability, homogeneity, pH, non-greasy and no evidence of phase separation during study period. Stability parameters like visual appearance, nature, viscosity and fragrance of formulated creams showed that there was no significant variation during the study period. All nine herbal cold cream formulations showed significant activities. Based on the results, we can suggest that all the nine formulations F1, F2, F3, F4, F5, F6, F7, F8 and F9 were stable and can be safely used on the skin. 




Lakhan D. Baheti*, Aditya R. Pachghare, Anuja V. Deshmukh, S. C. Atram
Vidyabharati College of Pharmacy, C.K. Naidu Road, Camp, Amravati, Maharashtra – 444602.

Computer aided drug development (CADD) comprises of a broad range of theoretical and computational approaches, CADD method have a major role in modern drug discovery, design and development that plays a major part in clinical use and clinical trials .it also highlights the current trends and methods used in development of novel methods i.e. computer aided repurposing and emerging concepts and technologies in molecular modeling and chemo informatics. In this once the drug molecule is identified/selected it is processed for development. In which different parameters of lead compound are assessed on basis of vitro assay (experimental analysis), vivo model (animal studies) and silicon approach (software based). From the last decade incremental developments in R&D processes, the selection of tools for optimizing the functionality and viability has become the important factor in early drug development and is said to be the key for development of effective therapeutic agents. Drug design is important part of drug development, identification of active components in natural products gives lead compounds for development into drug. The current process of High Throughput Screening (HTS) through wet chemistry or in silicon is reviewed. The development of drug through protein engineering is used for antibody drug conjugates to improve specificity. HTS has the capacity to profile thousands of chemical concentrations response formats with reduce rate of false positive and false negative, therefore from last decade it used for compound libraries screening. Titration based quantitative screening is used for toxicology. 




Zaki Iqbal Ansari*, Dr. Avish D Maru, Mr. Yashpal More
Department of Pharmaceutics, Loknete Dr J D Pawar College of Pharmacy Manur (Kalwan), Maharshatra.

Gastro retentive floating drug delivery systems (GFDDS) of Atenolol, an antihypertensive drug, with an oral bioavailability of only 50% (because of its poor absorption from lower gastrointestinal tract) have been designed. Methocel, polysaccharides (e.g., chitosan), was used as the polymer and sodium bicarbonate as gas generating agent to reduce floating lag time. The tablets were prepared by direct compression method. The optimized formulation containing Atenolol 100 mg, Hydroxypropyl methyl cellulose 35 mg and Sodium bicarbonate 35 mg has displayed almost first order release kinetics with a floating lag time of only 101 second. This formulation released more than 96% drug in 6 hours. This study proves that GFDDS of Atenolol can be designed using, Hydroxypropyl methyl cellulose as polymer, which provides nearly first order release kinetics and thus possible enhancement of oral bioavailability of the drug. 



Matsyagiri Lenkalapally*, Dr. Hemamalini.K1, Yadagiri Yata2, Nagadevi Venkatesham Mulugu2, Renuka Hari Prasad Mannyam2
*Swami Vivekananda Institute of Pharmaceutical Sciences & Indus Viva Distributor (Star 1000), 1Swami Vivekananda Institute of Pharmaceutical Sciences, Vangapally (V), Yadagirigutta (Mdl), Yadadri-Bhongir (Dt)-508286, Telangana, India.
2Indus Viva Distributor , Yadadri-Bhongir (Dt), Telangana, India.

An evidence-based systematic review of acai (Euterpe oleracea) the acai (ah-sigh-EE) berry is a grape like fruit harvested from acai palm trees, which are native to the Amazon rain forests of South America. Like other berries, acai berries contain antioxidants and fiber. Acai berries are widely touted as a so-called super food, with proponents claiming that they are helpful for a variety of health concerns, including arthritis, weight loss, high cholesterol, erectile dysfunction, skin appearance, detoxification and general health. The acai extracts have a range of poly phenolic components with antioxidant properties, some of those present in greater quantity are orient in, isoorientin and vanillic acid, as well as anthocyanins cyanidin-3-glucoside and cyanidin-3-rutinoside. The presence of these substances is linked mainly to the antioxidant, anti- inflammatory, anti-proliferative and cardio protective activities. However, research on acai berries is limited, and the claims about their health benefits haven't been proved. Acai is usually safe to consume. This article includes written of historical background, active chemical constituents, nutrional values, health benefits plus a compilation of expert opinion, folkloric precedent, side effects, marketed products and dosing.