PREPARATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF VALSARTAN USING NATURAL POLYMERS
G.Ganesh Kumar*, P. Raghuveer, V. Ranjith.
Srikrupa Institute of Pharmaceutical Sciences, Vill. Velkatta, Kondapak, Dist. Medak, Siddipet, Andra Pradesh – 502 277.
Sustained release tablets of Valsartan were fabricated using pectin, guar gum and Xanthan gum. The tablets were evaluated for physical characteristic like hardness, weight variation, friability, and drug content. In vitro release of drug was performed in PBS pH 7.2 for fifteen hours. All the physical characters of the fabricated tablet were within acceptable limits. The tablet with guar gum exhibited greater swelling index than those with pectin and xanthan gum. A better controlled drug release (80.74%) was obtained with the matrix tablet (G4) made-up of the guar gum than with the pectin and xanthan gum. It is cleared through the dissolution profile of Valsartan from matrix tablets prepared using different natural polymers were retarded approx 15 hrs.