Ganesan A1, Rengasundari R2, Mudiganti Ram Krishna Rao3, Raguram Ganesan4
1Government Siddha Medical College, Chennai-106.
2Department of Nanju Noolum Maruthuva Noolum, National Institute of Siddha, Chennai-47.
3Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai- 600073.
4Jiamusi Medical University, Jiamusi, China.
The efficacy parameters of present day medicine depends on various scientific verifications such as pharmacological, pharmacokinetic, teratological and toxicological parameters. Ayurvedic and Sidhha medical practices, although age old methods of medicinal practice, have to prove their efficacy in these lines to get wider attention, recognition and acceptability. The present report is to study the toxicological effects of one Sidhha medicine, Kodasuri veeravaiuppu, on animal model. This medicine is used to treat inflammatory conditions such as rheumatism and arthritis in Sidhha practice. The parameters studied were water consumption, food consumption, body weight, kidney function test, liver function test and hematological parameters. The duration of the Study was for 45 days. Two dose levels of the test drug ‘Kodasuri veeravaippu’ were used (9.75 mg/kg and 16.15 mg/kg). Each group consists of six animals (three animals /sex /group). The drug was administered orally once daily for 45 days. It was observed that the medicine was quite safe when used at a lower dose of 6.75mg/kg, whereas, there was some moderate side effects, well within the permissible limit, at 16.15 mg /kg. Further work is on to understand the medicinal efficacy of this drug.