INCIDENCE OF MICROALBUMINURIA AMONG TYPE –II DIABETUS MELLITUS PATIENTS AND THE EFFECT OF ANGEOTENSIN RECEPTOR BLOCKERS IN ITS MANAGEMENT
Diabetes mellitus is a multifaceted condition that affects virtually every cell in the body and can leads to develop pathological changes in numerous organ systems. Leakage of small amounts of proteins approximately 30-300mg/day or 20-200μg/min through urine is termed as “Microalbuminuria” and it is considered as a crucial sign of early kidney disease in diabetic patients since 1980’s. In our study we arel calculate the incidence of Microalbuminuria in type - II diabetes mellitus patients, which are considered to be an early sign for diabetic complication like “Diabetic Nephropathies”. Microalbuminuria is a powerful predictor of cardiovascular disease and mortality in adults. This holds true in the general adult population but is particularly recognized in those with diabetes. There is a significant correlation between Microalbuminuria and blood pressure; even a high usual blood pressure can lead to Microalbuminuria with high frequency. By this way it is termed to be a biomarker for increased cardiovascular risk. Hyperglycaemia can lead to glomerular endothelial membrane damage. Renal involvement is a pivotal development in diabetes and Microalbuminuria is generally the first clinical sign of renal dysfunction in diabetics. Consequently, both DM and HTN patients are to be assessed for Microalbuminuria and to be treated with appropriate regimen like angiotensin receptor blockers (ARB’s e.g.; losartan) to prevent or delay the progression of the disease and also helps in reducing further complications of diabetes.