SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF 3,5-DISUBSTITUTED PYRAZOLINE DERIVATIVES CONTAINING PYRIDINE AND PIPERAZINE NUCLEUS
A series of new pyrazoline derivatives containing pyridine, piperazine and amide linkage were prepared through multi-step synthesis. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, LCMS and HPLC elemental analysis. All the synthesized pyrazoline derivatives were screened for their antimicrobial activity against Gram positive Staphylococcus aureus (NCIM-5022) and Gram negative Klebsiella aerogenes (NCIM-2098), Escherichia coli (NCIM-5051) bacterial and A. flavus and C. albicans fungal strains by agar well diffusion technique along with anthelmintic activity using P. posthuma. It was found that all the compounds showed less antimicrobial activity, whereas significant anthelmintic activity was witnessed for the tested series. Compounds 11c, 11d and 11e were the most potent anthelmintic agents of the tested series.