SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME SUBSTITUTED PYRIMIDINE DERIVATIVES
Osman Ahmed*1, Syed Azeemuddin Razvi1, T K Md Rayees1, M A Nafay Shoeb1, Md. Salahuddin2
1Department of Pharmaceutical Chemistry, Deccan School of Pharmacy, Hyderabad, A.P. India.
2Department of Pharmaceutical Chemistry, Farooqia College of Pharmacy, Mysore, Karnataka, India.
The main objective was to synthesize and characterize novel pyrimidine derivatives and screen them for anti-inflammatory activity. A series of four 6, 7-dihydro-3-aceto substituted pentaleno [2, 1-d] pyrimidin-4-one derivatives (PM1-PM4) were synthesized from 2-amino-3, 4, 5, 6-tetra hydro pentalene-1-carboxamide. The synthesized compound, characterized on the basis of satisfactory analytical and spectral (H1NMR, C13Mass) and elemental data. Studies were carried out for the synthesized compounds which were also evaluated for anti-inflammatory activity by Carrageenan induced rat paw edema method. Indomethacin was used as standard anti-inflammatory agents. The synthesized compounds showed good anti-inflammatory activity, compared to standard drugs. Two of the compounds PM2 and PM4 exhibited significant anti-inflammatory activity, as compared to standard drug Indomethacin. We reported the successful synthesis of novel pyrimidine derivative, as well as their spectral characterization.