Sitagliptin is an orally administered, potent, and highly selective inhibitor of dipeptidyl peptidase-4 (DPP-4) and was the first agent of its class to be approved for use in the management of adults with type 2 diabetes. Numerous randomized placebo- or active comparator-controlled trials have demonstrated the efficacy of sitagliptin in terms of improving glycaemic control in patients with type 2 diabetes, including its use as monotherapy, initial combination therapy (usually with fixed-dose combinations ofsitagliptin/metformin), or add-on therapy to metformin or other antihyperglycaemic drugs, with or without metformin. Sitagliptin was generally well tolerated in clinical trials, had a low risk of hypoglycemia (although this depends on background therapy), and had a neutral effect on body weight.It stimulates insulin secretion when hyperglycemia is present and inhibits glucagon secretion. In clinical studies, it is weight neutral. This article gives an overview of the mechanism of action, the pharmacology, and the clinical efficacy and safety of sitagliptin in type 2 diabetes therapy.

Parkinson’s ailment is especially outstanding from other situations based totally on the vital function of tremors. Oxotremorine-triggered oxidative pressure is a commonplace pathway in growing Parkinson’s signs like tremors, salivation, and temperature version. Subsequently, the Oxotremorine-precipitated tremor version changed used to assess Antiparkinsonian tablets. Distinct Anthraquinones derivatives compound 1 to16 have been formulated using appropriate schemes 1to 4 to investigate the Antiparkinsonian impact on Oxotremorine-brought on Parkinson’s symptoms in mice. Procyclidine, an anticholinergic, Antiparkinsonian drug was administered as a generic drug at a dose of 5 mg/kg p. o., 1hr prior to the administration of Oxotremorine (0.5 mg/kg) S.C. Numerous synthetic Anthraquinones compounds administered 200 mg/kg p. o. route of administration to reduce Parkinson’s symptoms. This look at indicates synthetic Anthraquinones compounds 1, 2, 6, eight, 12, and 14 show marked response to Parkinsonism symptoms compared to Procyclidine. From this research it is always worthy to synthesize various novel amino Anthraquinones compounds by considering Carboxamide linkage with various heterocyclic compounds as a neuroprotective agent helpful in PA.

Today, about 74% of medications are taken orally, and many people do not find them as effective as they would like. To improve these properties, transdermal drug delivery systems have been developed. The deck system of the transition drug includes the production of pharmaceuticals on the skin to have a topical therapy effect, and the largest of the drug is transported by systematic circulation and quality. The modern administration of therapies offers a lot of advantages compared to the traditional methods of recovering oral and invasive drugs. In addition to transitional medicines, other than the drug, the first metabolism and therapeutic efficiency increases and maintains its normal condition.

Today, about 74% of medications are taken orally, and many people do not find them as
effective as they would like. To improve these properties, transdermal drug delivery
systems have been developed. The deck system of the transition drug includes the
production of pharmaceuticals on the skin to have a topical therapy effect, and the largest of
the drug is transported by systematic circulation and quality. The modern administration of
therapies offers a lot of advantages compared to the traditional methods of recovering oral
and invasive drugs. In addition to transitional medicines, other than the drug, the first
metabolism and therapeutic efficiency increases and maintains its normal condition.

Onychomycosis, also known as tinea unguium, is a fungal infection of the nail bed or nail plate. It affects approximately 14% of the world's population and accounts for approximately 50% of all nail diseases. Dermatophytes, non-dermatophyte moulds, and yeast are the most common causative organism. It was initially thought to be a cosmetic issue but has recently gained attention due to its persistent nature and difficult treatment with relapses. Onychomycosis is typically treated with oral and topical medications. Although effective, oral antifungal agents are hepatotoxic and cause drug-drug interactions. Topical therapy is more patient-friendly because it does not have these side effects, but it has another disadvantage of improper nail penetration. Efforts have been made for decades to improve topical delivery for the effective treatment of onychomycosis. Mechanical, physical, and chemical methods were used. Despite all efforts, the nail delivery problem remains unresolved. For improved drug permeation and localized therapy, the emphasis has recently shifted to novel drug delivery systems such as nanoparticles, microemulsions, polymeric films, and nail lacquers. This review article discusses both conventional and novel formulation approaches for the treatment of onychomycosis.

Periodontitis is an inflammatory disease of the tooth-supporting tissues caused by specific microorganisms. The idea of treating localised problem sites with local drug delivery seems appealing because the antimicrobial agent is delivered within periodontal pockets and the therapy is directed at specific pathogenic microorganisms. A novel in situ forming gel is introduced at the site, with the potential to overcome one of the main practical challenges associated with the treatment of local periodontitis: partial adhesion to the surrounding tissue, resulting in the accidental removal of at least parts of the implants from the patient's pockets. For the treatment of localised forms of periodontal destruction, controlled release antimicrobial agents should be considered as an adjunct to mechanical debridement. Local delivery of an in situ gelling system to periodontal pockets has the advantage of putting more drugs at the target site while minimising total body exposure to the drug The most appropriate type of formulation for the treatment of periodontitis has been found to be oral in situ gel because it delivers the drug locally, allowing the dose to be reduced while also reducing toxicity. In situ gel formation can be caused by a variety of mechanisms, including solvent exchange, UV irradiation, ionic cross-linking, pH change, and temperature modulation.Here we highlight about the methods of oral in situ hydrogel, polymers used in the preparation and also examines periodontitis pathogenesis as well as its diagnosis and treatment.

The presented study's recent literature review of oral antidiabetic pills their chemical nature, structure for Category 2 diabetes mellitus (DM) is a disorder this is putting a growing burden on health carrier delivery internationally. Therefore, it has to turn out to be more and more crucial that physicians who deal with such patients have an excellent understanding of antidiabetic capsules which might be currently to be had or will come onto the marketplace. This newsletter offers a top-level view of all of the significant drug lessons in addition to some statistics on pharmacokinetics, pharmacodynamics, aspect-impact profiles, and indications to be used.

Ayurveda is based on 3 principles PanchamahabhutaSidhhanta, Tridosha, Guna Rasa ViryaVipakaPrabhavaSidhhanta.Charak and Sushruta made significant contribution to Ayurveda. By Balancing tridoshas Ayurveda maintain the health of skin. The human skin plays significant role in physiological functions of sensation, protection and thermoregulation. The procedures of skin care given in the Ayurvedic classics are purely natural and they improve the skin health as compared to modern cosmetic products. Ayurvedic skin care products having a various therapeutic properties and are used for treatments of condition such as photosensitivity, ageing, finelines, wrinkles, dark spots, etc.A Large number of Ayurvedic product have been developed for skin care e.g. Asava – Arista, Avaleha. Paste, Natural Powder, Lepa.Some  medicinal plants used in skin care are aloevera, turmeric, ginger, neem,etc. They can be sold as tablet, powder, gels, sunscreen,creams, teas,etc. They are safe and effective. Many chemicals and synthetic ingredients used in many skin care product can causes variety of undesirable side effects.This review present the concept of Ayurvedic product which are natural and chemical free have number of benefits and healing repairing effects on skin.Ethnobotanical dermatology in India confirms the belief that their analysis will accelearate the discovery of new effective therapeutic agents for skin care.