EXPLORING THE EFFICACY OF ACACIA CATECHU-MEDIATED GREEN SYNTHESIS OF SILVER NANOPARTICLES FOR INFECTION CONTROL IN BURN WOUNDS
A Chougle*, A Joice
Department of Pharmaceutics, M.C.E Society’s Allana College of Pharmacy, Pune.
The present research explores the use of eco-friendly silver nanoparticles (AgNPs) created through a green method, employing Acacia Catechu extract, to combat infections in burn wounds. The successful synthesis of AgNPs was confirmed using UV-Visible spectroscopy, with the extract acting as a reducing and stabilizing agent. The AgNPs' size and shape were determined through Scanning Electron Microscopy and Zeta Sizer. These nanoparticles displayed potent antimicrobial properties against a range of bacteria commonly associated with burn wound infections, showing promising results in agar well diffusion assays and minimum inhibitory concentration (MIC) determination. The antimicrobial action involved disrupting microbial cell membranes and generating reactive oxygen species (ROS), leading to oxidative stress within the cells. The green synthesis approach presents a sustainable alternative, avoiding hazardous chemicals, and the natural plant extracts may contribute to wound healing and anti-inflammatory properties, further enhancing the therapeutic effectiveness of the AgNPs. This study underscores the potential of Acacia Catechu-mediated AgNPs as a valuable solution for preventing infections in burn wounds, prompting further investigation into their in vivo effectiveness, wound healing capabilities, and long-term stability. Ultimately, this research concludes that Acacia Catechu-mediated AgNPs hold promise for safer and more effective wound care