Formulation and Evaluation of Perindopril Erbumine Buccal Films
M.Aruna*,Y.S.Manjunath, G.Ganesh Kumar
Srikrupa Institute of Pharmaceutical Sciences,Vil. Velkatta, Mdl: Kondapak, Dist. Medak, Siddipet, Andhra Pradesh – 502 277, India.
Abstract
The buccal region of the oral cavity is an attractive target for administration of the drug of
choice. To increase bioavailability and prevent first pass metabolism of drug, Perindopril
Erbumine was embedded in sustained released buccal patch over period of 6 hour. The
objective of present work was to characterize the effect of HPMC with Eudragit, sodium
CMC and EC for water soluble drug by preparing mucoadhesive buccal patch. Each
formulated batch was subjected to various evaluation parameters. The swelling percentage
was found to be function of solubility of drug and polymer. The mucoadhesive strength and
in-vitro released of water soluble drug through water insoluble HPMC base matrix were found
satisfactorily. The physical appearance of buccal patch was examined by scanning electron
microscopy. In the present study, attempts were made to prepare and evaluate the Buccal
films containing Perindopril hydrochloride, an antihypertensive drug using Hydroxy propyl
methyl cellulose, Eudragit RL-100, Eudragit RS-100, Dichloro-Methane, Methanol. The
results showed that buccal patches prepared Using 15% propylene glycol w/w of polymer
weight was found to have good physical characteristics. A remarkable increase in thickness,
FTIR, drug content uniformity, drug release and stability studies percent swelling index,
percent moisture uptake and mechanical properties with an increase in the percent hydrophilic
polymer (HPMC). All the patches were, thin, smooth and flexible, uniformity in drug content,
weight and thickness were observed with their low SD values. In-vitro drug permeation
through sheep buccal mucosa was performed using Franz diffusion cells. The film showed
maximum permeation at the end of 6 hrs. The release mechanism from all membrane
controlled systems followed diffusion mechanism. All the systems were found to be stable
with respect to drug content as well as physical changes at 400C and 75% RH.