Quality Control (QC) testing performed for an extensive variety of purchaser and mechanical items. It also give Quality Control testing to the pharmaceutical business, including Active Pharmaceutical Ingredients (APIs), intermediates, excipients, and completed items, for example, tablets, cases, creams, moisturizers, fluid arrangements, and transdermal patches. A quality control lab can decide the reason and understand current item disappointment and if utilized legitimately can even forestall future issues. Incidental group to clump testing will guarantee that after some time your items thickness, shading, scent, execution, and piece stay reliable over the long haul. As specified before it is additionally brilliant to check the nature of crude materials with an autonomous testing research center at whatever point parts providers are changed or in the event can see a sudden contrast in the nature of crude materials being gotten. 

End Stage Renal Disease is a medical condition which occurs when a person’s kidney stops functioning, where dialysis is done to remove wastes from the body. Depression is identified as the most common psychological problem among dialysis patients. Hence it is mandatory to evaluate depression and to reduce its psychological symptoms through patient counselling. The intention of this study is to assess the periodicity of depression among hemodialysis patients. The prospective observational questionnaire based study was conducted for a period of 6 months in the Nephrology department of a tertiary care teaching hospital, Davangere. A sample size of 50 patients was enrolled and randomized into case and control groups. The study used specific data collection form and depression was determined using Beck Depression Inventory (BDI) questionnaire. The questionnaire was applied before and after patient counseling for both groups. At the end of the study, a significant reduction (p<0.05) in the BDI score have been observed in the case group of study population, who received patient counseling and patient information leaflet. This study tried to entitle the name of pharmacist as a patient educator who gives proper guidance to the patient and also the family members about the disease, drug management, diet and life style modifications. We conclusively state that clinical pharmacist can play a key role in reducing the depression through psychosocial interventions, thereby enhancing the health related quality of life among dialysis patients. 

Chemo/Radiation induced oral mucositis is a significant problem in cancer patients undergoing therapy.It is a major dose-limiting toxicity of chemo-radiation therapy in various cancers. Ayurveda has explained conditions such as sarvasaramukha paka which are disease conditions similar to oral mucositis. There are various ayurvedic herbs with proven effect in managing and preventing chemo-radiation induced oral mucositis. Ayurveda can offer a healthy alternative to management of chemo/radiation induced oral mucositis.Future research can point to the specific ayurvedic treatments in oral mucositis imbibing the principles of Ayurveda and not focusing just on the pharmaco analytical profile of certain plants alone. 

Osimertinib mesylate is a kinase inhibitor, prescribed for the treatment of patients, who are diagnosed with metastatic epidermal growth factor receptor (EGFR) T790M mutation positive non-small cell lung cancer (NSCLC). The Innovator of the product is AstraZeneca and its brand name in US and EU market is TAGRISSO® (Osimertinib) 40 mg and 80 mg film coated Tablets. The recommended dose is one 80 mg tablet once daily taken orally with or without a meal. Approximately, 80-90 % of lung cancer comprise NSCLC. Solubility of Osimertinib is known to be affected by pH, it belongs to BCS class-III molecule. The current work attempted to study the impact of both particle size of API and concentrations of disintegrant (L-HPC) on in vitro drug release profiles of Osimertinib from tablet dosage form in comparison to in vitro drug release profiles of corresponding Innovator product in US market. Based on the scientific discussion of TAGRISSO® in EU market, and to increase the flow properties of blend for compression into tablets, dry granulation method (by Roller compaction) was adopted. Assay and in vitro dissolution of the finished product was analysed by UV method. The obtained dissolution results suggested that 500 ml of pH 4.5 Acetate buffer at 25 rpm was found to be more discriminatory media than pH 6.8 Phosphate buffer and pH 1.3 (containing 0.2 % NaCl) and film coated tablets with input micronized API (<10?) has shown similar physical characteristics (hardness, disintegration time) and in vitro drug release profiles to that of Innovator product. 

The isolation of oil contaminated sites and gravimetric analysis of degradation in which, two bacterial formed maximum clearing zones on minerals salt medium. An increase in cell number indicating that the bacterial isolation was responsible for the oil degradation. The collected oil contaminated sites at kormongala, Indra nagar, MTTC culture, micrococcus spp., Bacillus spp., pseudomonas spp., which are able to utilize the oil in soil as carbon sources, were added to oil contaminated soil sample, the growth profiles were determined by monitoring the optical density, dry weight and Ph of the culture utilizing lubricating oil as sole sources of carbon, Bushnell Haas media supplemented with petrol, kerosene and diesel as sole carbon sources was used for isolation of bacteria capable of degrading these petroleum fractionates. From three soil sample and two water sample, a total of nine bacterial strains were isolated capable of degrading petrol, kerosene and diesel with varying tolerance capacities, the isolates were identify by using standard biochemical test and morphological studies and it was determined that these strains belong to six bacterial genera .the present study suggest that the isolated bacterial species could be employed for bioremediation in environment polluted with petroleum and its products, indigenously from the soil and water contaminated with crude oil in the vicinity of oil drilling well were found to be most efficient crude oil utilize as turbidity observed by spectrophotometrically. In the various study of lipolytic bacteria concluded that the taken of oil contaminated soil from from petroleum bunk and to identify their biochemical characterization by using various sources. How it’s helpful for characterize by using of lipolytic bacteria. 

Migraine is primarily a female disorder that has been associated with sex hormones. Throughout the reproductive years, the migraine prevalence is about three times more in women than in men. The occurrence of migraine may be influenced by menarche, menstruation, pregnancy, and menopause. Migraine usually starts after menarche, and occurs few days before or during menstrual cycle. The period of highest chances for migraine in susceptible women corresponds to estrogen withdrawal in the late luteal and early follicular phases of the menstrual cycle. This review concludes that migraine particularly affects women due to the hormonal changes throughout their lifecycle. 

In ocular drug delivery system (ODDS) majority of medications are delivered as eye drops and these may reduce the intraocular pressure but having major deficiencies like low patient compliance and low bioavailability. Therefore, ophthalmic drug delivery has become very fashionable with their distinctive benefits like extended drug release and more than 50% bioavailability. To achieve controlled and sustained drug deliveries from contact lenses, we tend to come that numerous techniques like compounding into nanoparticles, micelle, liposomes have many technologies in developing the load of a drug connected lenses like soaking, molecular acquisition, defense of drug loaded mixture nanoparticles, ion ligand polymeric system. Some of the major disadvantages to this technology are corneal problems, conjunctivitis etc. The rate of drug delivery is not constant overtime with the bulk of medicine within the lens being delivered within the initial stage rather that at end of treatment period. 

OBJECTIVE: To establish PCR based detection assays for dup A, ice A, hom B genes of H. Pylori and detect the presence of these genes in Pakistani H. Pylori isolates, and to examine other confounding factors beside dup A, ice A, hom B such as age, gender, diet and lifestyle characteristics with association of H. Pylori-related diseases METHODOLOGY: This cross-sectional analytical study was conducted at gastroenterology Department, Shaikh Zayed Hospital, Lahore and molecular techniques were performed in Centre of Excellence and Molecular Biology, University of Punjab, Lahore, with duration of two years. All the cases with symptomatic dyspeptic patients either gender and with age more than 18 years were included in the study. All the subjected patients were undergone to endoscopic examination. Upper gastrointestinal endoscopy was carried out and specimens were obtained for the gastric biopsy. Specimens were inoculated in the CLO or rapid urease test gel and rest were stored in eppendorf tubes containing normal saline at -20C until DNA extraction. DNA was extracted of the H-pylori by using Gentra DNA extraction Kit (Life Technologies, USA) according to instructions given in protocol of the kit for Qualitative PCR detection of DNA of H. Pylori. The PCT primers sets were designed for the specific detection of dup A, ice A and hom B gene of H. Pylori using primer 3 software. The designed PCR primer sets specific for the H. Pylori dup A, ice A and hom B genes were used for PCR amplification. PCR was performed for the amplification of dup A, ice A and hom B genes. The desired genes were quantified using Real-time PCR. The PCR bands of the amplified genes were gel eluted and were stored at minus 20 degree C till to be used for sequence analysis. RESULTS: Mean age of the cases was found 41.22+8.04 years. Male were more affected 118 (60.2%) as compare to female 78(39.8%). Epigastric discomfort was found in the 196(100%)of the cases where as Bloating and Belching cases were noted as 180(91.8%) while Nausea a & vomiting cases as observed as 138(70.4%). The life style distribution exhibited that Hand wash 188(95.9%)was observed most frequent in all cases and exercise 36(18.4%) of cases, however municipality source water was more common following by Fresh water 48(24.5%) and Filtered water as 4(2.0%) of cases. As indicated by this study CLO/rapid urease test as well as Polymerase chain reaction quantity was noticeably 100% positive in all cases. As per H.pylori genes distribution Hom B was the most common 76(38.8%). A significant association was found in the gene distribution of the H. pylori among both genders male were more linked to Dup A, while female were mostly associated with Ice A and Hom A genes, P-value 0.001. Different type of diets is significantly associated with h pylori genes P value 0.001. Water bad sources were highly associated with h pylori genes as genes were mostly found in municipality water as compare to filtered and fresh water p- value 0.001. CONCLUSION: prevalence of hom-B gene most frequent as compare to Dup A and ice A genes, in the patients having dyspepsia. These genes were strongly associated with bad life style and bad sewerage system along with some poor dietary habits.