Rasika D. Bhalke, Seema A. Gosavi, Mahendra A. Giri
Sanjivani College of Pharmaceutical Education and Research Kopergaon,
A/P- Kopergaon, (Pin- 413736), Tal- Kopergaon,, Dist-Ahmednagar, Maharashtra, India.
Argyreia nervosa has long been used in indigenous system of medicine, to treat chronic ulcers, gonorrhea, strangury and gleet. Therefore, Present study was designed to investigate the antiulcer effect of hydro alcoholic leaves extract of A. nervosa (HLEAN) using different models of gastric ulceration in rats. Acute gastric ulceration in rats was produced by oral administration of various noxious chemicals including aspirin or ethanol or indomethacin. Anti-secretory studies were undertaken using pylorus-ligated technique. Gastric total acid output and pepsin activity were estimated in the pylorus ligated rats. Gastric tissue was also examined histologically. HLEAN was administered in the dose of 400 mg/kg orally in all experiments. Omeprazole, ranitidine, misoprostol were used as a reference drug. The antiulcer activity was assessed by determining and comparing the ulcer index in the test drug group with that of the vehicle (negative) control group and standard (positive) control group. HLEAN at the dose of 400 mg/kg produced a significant reduction in the ulcer index. HLEAN significantly inhibited gastric mucosal damage induced by aspirin, ethanol and indomethacin. In pylorus-ligated Shay rats, HLEAN significantly reduced the basal gastric acid secretion, acidity. HLEAN reduces pepsin activity. The anti-ulcer effect was further confirmed histologically. The anti-ulcer activity of HLEAN was however, less than that of standard drugs. The present finding suggests that protective effect of HLEAN might have been mediated by both anti-secretory and cytoprotective mechanisms. Moreover, further insight into the precise mechanism of action is essential to exploit the complete potency of HLEAN and increase its usage in contemporary medicine.