PREPARATION AND OPTIMIZATION OF POLYMETHACRYLATE RESIN BASED SUSTAINED RELEASE LOSARTAN POTASSIUM MICROCAPSULES BY USING MINITAB16® SOFTWARE
This study is an attempt to formulate sustained release Losartan potassium microcapsules using a combination of Polymethacrylate resin based polymers (Eudragit RSPO and Eudragit RLPO) by a newly developed modified double emulsion solvent evaporation method. A 32 full factorial design which comes under Response Surface Methodology (RSM) was used to study the effect of independent variables like drug: polymer ratio (X1) and stirring speed (X2) on specific selected responses like particle size and entrapment efficiency. The whole optimization was done by using statistical software Minitab 16® trial version. With the help of software the selected best batch of formulation F3 exhibited a particle size of 292 μm and entrapment efficiency of 84%. Further characterization of optimized microcapsules for surface morphology was also done and release of the drug from prepared microcapsules was sustained for more than 14 hours. The present study exhibited a software based methodical way to find the optimized best formulation and also prove the sustained release property of the prepared microcapsules.