Two novel coordination compounds, [Zn(L)2(OOCH)2] 1 and [Zn(L)3(OCHO)](OCHO)]·H2O 2 (where L = 2-isopropylimidazole, C6H10N2) have been prepared by reaction of 2-isopropylimidazole with zinc(II) formate at room temperature using toluene as solvent. These compounds were characterized by elemental and thermal analyses, IR, 1H-NMR and 13C-NMR spectroscopies, single crystal X-ray diffraction and DFT studies. The Zn centers in 1 and 2 adopt pseudo-tetrahedral coordination geometries. Compound 1 crystallizes in the monoclinic system P2/c space group whereas compound 2 crystallizes in the P-1 space group of the triclinic crystal system. Several types of hydrogen intra-/intermolecular interactions are observed in these materials and extend into a two-dimensional leaf like network in 1 and a two-dimensional lattice of rectilinear pillars in 2. Compounds 1 and 2 were also optimized and their frontier molecular orbitals, global reactivity descriptors, molecular electrostatic potential, natural bond orbitals were investigated using density functional theory (DFT). In fact the induced structural differences from complex 1 to complex 2 led to the reduction of the frontier molecular orbital energy gap by 1.338 eV and a decrease of the chemical hardness by 0.669 eV. 

The medical industry nowadays is greatly impacted by technology, which also has an impact on pharmacies. One fundamental area of computer science that has influenced every field of science and technology, from basic engineering to pharmaceuticals, is artificial intelligence (AI). As a result, artificial intelligence (AI) is now being used in the healthcare industry, which includes pharmacies. The ability of machines to behave and perform like humans is referred to as artificial intelligence. It simulates human intelligence and facilitates more intelligent problem solving. The goal of this article's is to shed light on the significance of artificial intelligence technology and how it should be used responsibly when dispensing drugs. Over the last few years, there has been a noticeable increase in interest in the applications of AI technology for the analysis and interpretation of several significant pharmacy domains, including drug development, dosage form design, poly pharmacology, and hospital pharmacy. AI also will be used in the pharmaceutical industry to assist researchers in making decisions on new therapies for ailments and existing medications. It will also speed up the clinical trial process by identifying the appropriate individuals from a variety of data sources. When implementing AI in pharmacies, there are a number of benefits and drawbacks, thus it's critical to apply AI responsibly. 

Objective: To assess the type of conversion therapy from intravenous to oral antibiotics among hospitalized patients and the criteria preferred for conversion therapy. Materials and Methods: This observational study conducted for a period of 6 months at SHRC Tumakuru, Karnataka. A total of 127 patients from the hospital’s inpatient department were included in the study. The data were collected, analyzed, and interpreted using descriptive statistics. Results: Among 127 cases, 100 (78.74%) patients were converted and 27 (21.26%) patients were not converted, males (55.12%) are more suffered, and the age group above 60 years (33.07%) are more hospitalized. Cephalosporin (53.93 %) antibiotics were the commonly prescribed class of drug in which ceftriaxone (54.00%) was preferred. Among the conversion therapy, step-down therapy (43.00 %) was commonly used. T-test revealed that there exists no statistical difference in length of hospital stay (P value 0.5360) and duration of IV therapy (P value 0.2501) among converted and non-converted groups. 10% of patients had a conversion of antibiotics from Broad spectrum to narrow spectrum, Both Patient stability and plan for discharge were found to be 100% respectively. Conclusion: Our study concludes that male patients are more hospitalized and systemic fever is most common. Step down was the commonly preferred type of conversion to treat patients. Cephalosporin antibiotics are preferred in patients for both IV and oral routes to treat disease conditions. Clinical pharmacist needs to review the conditions of patients for early conversion of IV to oral antibiotics to prevent irrational use of antibiotics. 

The global health challenge of antibiotic resistance calls for the development of innovative medicines. Combination treatment with licensed antibiotics using inhibitors that target intrinsic resistance systems offers a different approach to creating effective therapies. Since the mid-1940s, when the first aminoglycoside antibiotic, streptomycin, was introduced into clinical practice, aminoglycoside antibiotics, or AGAs, have been used extensively to treat clinical bacterial infections. However, the bacterial resistance to aminoglycoside is increasing day by day. The overexpression of the active efflux pump gene, methylation of the 16S ribosomal RNA subunit, and alteration of aminoglycoside-modifying enzymes are the causes of bacterial resistance to AGAs. These modifications result in altered AGA structures and reduced drug concentrations in the bacteria. AGAs are difficult and time-consuming to develop because of their adverse effects and bacterial resistance. The antibacterial activity of the combination was found to be not only better than that of AGAs alone but also reduced the dosage of antibiotics, hence lowering the occurrence of side effects. This is because bacterial resistance may emerge shortly after application in practical practice. The development that is of special relevance is a recent one in which AGAs and other drugs have been combined to create a synergistic antibacterial action that provides a fresh strategy to counteract bacterial resistance to AGAs.