This work was conducted to find out a natural compound capable of inhibiting the Nucleocapsid protein present in the HTLV-1 virus. HTLV-1 virus belongs to delta retroviruses that do not contain protooncogene in their genome. Computer-aided drug design approach was used to obtain inhibitory compounds. A total of 109 natural compounds were identified by conducting a literature survey. PubChem database was utilized to retrieve the compound structure in 2D format. HTLV-1 NC (Nucleocapsid) protein was taken from the protein data bank. Molecular docking method was used to find out the compound capable of binding with the target protein. Compounds with good binding affinity were selected and further ADMET analysis was done. The final list of the compound with satisfactory ADMET profile and binding score were scrutinized using protein and ligand interaction results. The compound Miraxanthine_V was found to have a good binding affinity with said ADMET properties and was further studied for its structural stability with the target protein. Molecular dynamic simulation studies for 10 ns were done to check the stability of the protein and ligand complex during a simulation. Parameters like RMSD, RMSF, and radius of gyration were observed to understand the fluctuations and stability. the values obtained with simulations were found to come under the acceptance limit. We are proposing Miraxanthine_V as a potential inhibitor for HTLV- infection. 

Exposure to Anticonvulsant drugs by pregnant women to prevent seizures are among the most common causes of potential harm to the foetus. Even though prenatal exposure to antiepileptic drugs (AEDs) is known to cause relatively higher risks of major congenital malformations, prospective studies have provided refined data that allow us to differentiate the risks of different types and doses of AEDs. Women with epilepsy (WWE) are recommended to continue antiepileptic drugs (AEDs) during pregnancy to reduce maternal and foetal trauma associated with seizures. Substantial pharmacokinetic changes occur with most of the medications during pregnancy and postpartum, and inter individual variability supports the use of therapeutic drug monitoring for most AEDs. During pregnancy, vigilance and close monitoring should also include intrauterine foetal growth, obstetric complications, and neonatal complications. 

A simple, rapid, specific and accurate RP-HPLC method was developed and validated for the estimation of venlafaxine hydrochloride in pharmaceutical dosage form. The method involved an isocratic elution of venlafaxine hydrochloride in ODS C18 column using mobile phase consists of methanol : ortho-phosphoric acid (90:10 v/v). The wavelength of detection was 225 nm. The method showed good linearity in the range of 7.5-37.5 ?g/mL with correlation coefficient of 0.9981. The retention time was 2.41 min. The method was statistically validated for accuracy, precision, linearity, ruggedness, robustness, solution stability, selectivity and sensitivity. The results obtained in the study were within the limits of ICH guidelines. The results showed that this method can be used for rapid determination of venlafaxine hydrochloride in pharmaceutical capsule dosage form with precision, accuracy and specificity. The proposed method can be used for routine quality control samples in industry in for the estimation of venlafaxine hydrochloride in bulk and in finished dosage form. 

Pavetta indica is used in traditional and ayurvedic medicines. Its biochemical, antioxidant and cytotoxic properties were evaluated in the present study. Methanol and aqueous extract of Pavetta indica showed a significant antioxidant activity. Cytotoxic effect on normal cell lines was negligible. So it can be used in function food as an antioxidant agent. 

This Bioanalytical UV-spectrophotometric technique is quite simple, accurate, precise, reproducible, and sensitive. This bioanalytical method for determination of carvedilol. This UV-spectrophotometric method has been used for quantification of Carvedilol in tablet formulation also. The validation procedure confirms that this is an appropriate method for their quantification in the plasma and formulation. It is also used in routine quality control of the formulations containing this entire compound. In spectrum Carvedilol showed absorbance maximum at 289 nm. Validation parameters like linearity was found fron 5-30 ?g/ml accuracy was found to be 99.68%, precision was found to be within limit of 98% to 102%.For Ruggedness % RSD was also found less than 2 %. 

Plants have been one of the important sources of medicines since the beginning of human civilization. There is a growing demand for plant based Medicines, health products, Pharmaceuticals, Food supplements, Cosmetics etc. Barleria prionitis Linn belonging to Acanthaceae family is a small spiny shrub. It is an indigenous plant of South Asia and certain regions of Africa & India. Various parts of the plant such as leaves, roots, aerial parts, flowers & stems are used as an Antiarthritic, Antibacterial, Antifertility, Antioxidant, Antidiabetic, Antifungal, Antiviral, Hepatoprotective, Enzyme inhibitory, Anthelmintic & Anti-inflammatory agent. It is reported to certain flavonoids, saponins, glycosides, phytosterols & tannin. The plant contains some specific compounds such as barlenoside, barlerine, acetylbarlerine, balarenone & some common secondary metabolites. A review of chemical constituents present in various parts of B. prionitis & their Pharmacological actions is given in the present article. 

Weak aqueous solubility and poor oral bioavailability are main constraints in the production of new products. One technique used to increase the solubility of poorly aqueous soluble drugs is crystallization, which also helps to enhance physicochemical properties such as melting point, tablet power, solubility, stability, bioavailability and permeability with the preservation of pharmacological properties of the active pharmaceutical ingredient. In the medical and pharmaceutical industries, co crystals can be used to improve various properties, such as dissolution rate, melting point, solubility, chemical stability, etc. To increase the solubility of weak aqueous compounds, crystals are used to increase the solubility of aqueous compounds that are weakly soluble. It has the capacity to alter solid-state materials' physical properties. It is also used in taste masking, enhancement of mechanical property, and development and extension of intellectual property.