SYNTHESIS OF NOVEL 2-PHENYL-1,3- OXAZOLE DERIVATIVES AS NON-ACIDIC ANTI INFLAMMATORY AGENT AND EVALUATION BY IN SILICO, IN VITRO AND IN VIVO METHODS
Elessy Abraham1*, Anil V Chandewar2
1Prist University, Vallam, Thanjavur – 613403 (T.N.)
2P.Wadhwani College of Pharmacy,(Amravati University), Moha Fata, Yavatmal – 445001 (M.S.)
A series of novel 2-phenyl-1,3-oxazole derivatives ( 3 and 6-16) have been synthesized. The structures of these compounds were established by IR, 1H NMR, Mass spectral data and elemental analysis. Compounds were evaluated by in vitro anti inflammatory activity by human red blood cell (HRBC) stabilization method and were subjected to in silico prioritization for biological activity score (BAS) using PASS server. Molecules having acceptable BAS and with good HRBC stabilization activity were evaluated for their in vivo anti inflammatory as well as acute ulcerogenesis effects. Derivatives 8, 9, 11 and 14 exhibited good anti inflammatory activity in carrageenan- induced rat paw edema with very low ulcerogenicity compared with the standard drug diclofenac sodium.