Comparative Study of Novel Intraoral Rapid Dispersible Tablets and Films of Fexofenadine Hydrochloride
Pamu Sandhya *1, 2, Geetha Kodali1, Mariam Junaidi1, Sameera Khan1
1Department of Pharmaceutics, Shadan Women’s College of Pharmacy, Khairatabad, Hyderabad, India
2University College of Technology, Osmania University, Hyderabad, India
The purpose of this research was to select a suitable drug with negligible side effects and to formulate and evaluate it as fast dispersible tablets and films and to improve and compare the percentage cumulative drug release. Fexofenadine Hydrochloride is a non sedative, no impairing antihistamine used to treat seasonal allergic rhinitis (sneezing, runny nose, itchy nose, palate and throat or watery eyes), and urticaria (hives). Unlike most other antihistamines Fexofenadine Hydrochloride does not cross the blood brain barrier and therefore will not cause any drowsiness which can gradually effect child’s learning ability, drowsiness can also interfere with driving vehicles or operating machinery. During the work, intraoral rapid dispersible tablets were developed using superdisintegrants like Cross Povidone, Cross Carmellose Sodium and Sodium Starch Glycolate each in three different concentrations and in different combinations by direct compression method, these formulated tablets were subjected to pre and post evaluation parameters. All the physical characteristics were within the acceptable limits. A comparison of in vitro drug release of the optimized formulation was compared with the marketed product. Intraoral rapid dispersible films were also formulated using different polymers like HPMC E15 and HPMC 5 cP in different concentrations by Solvent Casting method, these films were evaluated and were within acceptable limits.