A PROSPECTIVE OBSERVATIONAL STUDY ON EVALUATION OF ANTIHYPERTENSIVE DRUGS IN HEMODIALYSIS PATIENTS IN A TERTIARY CARE HOSPITAL
Tima Babu*, Beya Baby, Ansalna Habeeb, Abijith R, Hesly Rajan, Sivakumar Thangavel
Department of Pharmacy Practice, Nandha College of Pharmacy, Perundurai Main Road, Erode, Tamil Nadu.
Aim: To study the evaluation of various antihypertensive drugs in hemodialysis patients in a Tertiary Care Hospital. Objective: A Prospective Observational Study was conducted to study and analyse the prescription pattern and efficacy of various antihypertensive drugs in hemodialysis patients. Methodology: In this study a total of 100 patients were enrolled based on inclusion and exclusion criteria. The study was conducted for six months in End Stage Renal Disease patients undergoing hemodialysis with hypertension. Effectiveness of antihypertensives was evaluated by monitoring blood pressure control. The patients were followed up for a period of 12 weeks. Results: A total of 100 patients were included in this study. Male patients (73%) were more compared to female patients (27%). The maximum number of patients was from the age group of 51-60 years (50%). In the present study, Calcium Channel Blockers (42%) and Beta Blockers (30%) were most commonly prescribed along with Diuretics. Efficacy of various antihypertensive drugs was evaluated by monitoring Pre-dialysis blood pressure. Calcium Channel Blockers with Beta Blockers and Diuretics have shown better efficacy than all other combinations. One tailed paired t test with alpha level of 0.05 was applied to compare the blood pressure before and after taking antihypertensives. Conclusion: Our study revealed that multi-drug therapy was more preferred than mono-drug therapy. Calcium Channel Blockers with Beta Blockers and Loop Diuretics were frequently prescribed and have shown more efficacy than other combinations. It has been concluded that prescribing of antihypertensives in an appropriate manner is helpful for improving the quality of life.