IAJPR

Indo American Journal of Pharmaceutical Research

ISSN NO.: 2231-6876
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1

FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL PATCHES OF PIROXICAM

Dr. Siraj Shaikh N*, Pathan Sharukh Y, G.J Khan, Shaikh Saad, Rehan Deshmukh
Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India.

The main objective of present investigation to formulate and evaluate mucoadhesive buccal patches of Piroxicam, using solvent casting method. HPMC K100 M were used as a mucocoadhesive polymer and PEG 400 used as a plasticizer as well as penetration enhancers. The formulated patches of piroxicam were evaluated for their appearance, weight variation, thickness, folding endurance, surface pH, swelling index, drug content, % elongation, mucoadhesive strength, in vitro drug release, kinetic release study and stability study. Among all formulated batches (S1-S8) of buccl patches batch S6 showing maximum drug release after 8 hours 94.77 % and mucoadhesive strength 10.21±0.35g). The stability study optimized batch S6 doesn’t show any changes with respect to previous evaluation carried out before stability study. It may concluded the mucoadhesive buccal patches of Piroxicam were successfully prepared using HPMC K100 M by solvent casting method, evaluated & it is better alternative to conventional drug delivery for the management of pain and arthititis.

2

OVEREVIEW MUCOADHESIVE MICROSPHERE: A REVIEW

Dr.Shaikh Siraj, Shaikh Saad*, Dr. G.J Khan, Shaikh Farhana, Patel Mohsin & Pathan Shahruk
Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India.

Now a day those dosage form which can control the release rate. The microspheres are producing target drug delivery at specific time limit. Microspheres are making important part in novel drug delivery systems. The microspheres are typical free flowing powders consist of synthetic polymer which are biodegradable in nature and having particle size less than 200 um. The microspheres are made from highly transparent glass can perform as much high quality optical micro cavities or micro resonators. The success of these microspheres is limited having provided intimate contact of the drug delivery system with the absorbing membranes. The mucoadhesive microspheres are prepared by using different polymers like HPMC k-4, Ethyl Cellulose, Eudrajit L-100, chitosan, sodium alginate, calcium chloride, guar gum and xanthun gum etc. The microspheres drug delivery system are benefited in various dosage form like nasal drug delivery system, oral drug delivery system, transdermal drug delivery system, colonic delivery, gastro-intestinal drug delivery system, ophthalmic drug delivery system, gene delivery and intra-tumoral drug delivery system. The microspheres are widely accepted to achieve parentral and oral release. Drugs that are easily absorbed from the gastrointestinal tract (GIT) and have a short half-life are eliminated quickly from the blood circulation, so they require frequent dosing. These review focous on overview of different aspect of mucoadhesive microsphere, different preparation method of microsphere as well as evalution parameter and applications of mucoadhesive microsphere.