The red blood cell distribution width (RDW) is a simple, low-cost biochemical parameter that reflects the level of anisocytosis as determined by a typical complete blood count. Anemia and other inflammatory disorders are diagnosed using RDW and other haematological parameters. Higher RDW levels have been implicated in numerous recent studies as a potent independent predictor of morbidity and mortality in a variety of cardiovascular diseases (CVDs). Therefore, RDW may be crucial in determining the severity and development of CVDs. In this review, we have outlined the mechanisms underlying the link between RDW and CVDs, as well as a few literature reviews that explain RDW and related CVDs, which demonstrated that even a 1SD increase in RDW causes various CVDs such as heart failure (HF), myocardial infarction (MI), atrial fibrillation, atherosclerosis, hypertension, and stroke depending on the degree of involvement. To varying degrees, some common mechanisms that contribute to increased RDW include oxidative stress, inflammatory cytokines, anemia, lipid abnormalities, vitamin D-3 deficiency, glycemic disturbance, chronic kidney disease (CKD), and liver disease. Finally, it can be concluded that even a 1SD change in RDW can indicate a significant risk of a CV event. 

Hyper pigmentation is a common skin problem in present days over the world In this condition there is increased in melanin production which ultimately results in darker patches of skins Due to overuse of topical corticosteroids under the influence of friends, relatives unfortunately leads to many adverse effects like hyper pigmentation, hypo pigmentation, straie, and rosacea. Here we describe two cases of hyper pigmentation induced by topical corticosteroids misuse. In case 1 the male patient came with the complaint of skin lesions over body and itching sensation since 5 months. He was using a topical corticosteroid cream ocosvate GM) on advice of para medical staff. In case 2 the 18 years female patient complaint about the skin lesions over body and itching since 4 years. She was using a topical corticosteroid cream Halobrt. On examination they both showed the signs of hyper pigmentation. The patches were significantly improved after the treatment recommended by dermatologist. 

Ziziphus jujube Mill. (Z. jujuba) is a traditional herb with a long history of use for nutrition and the treatment of a broad spectrum of diseases. It grows mostly in South and East Asia particularly in India, as well as in Australia and Europe. Mounting evidence shows the health benefits of Z. jujuba, including anticancer, anti-inflammation, anti-obesity, antioxidant, and hepato-protective properties, which are due to its bioactive compounds. Chemotherapy, such as with cis-diamminedichloroplatinium (CDDP, cisplatin) and its derivatives, is widely used in cancer treatment. It is an effective treatment for human cancers, including ovarian cancer; however, drug resistance is a major obstacle to successful treatment. A better understanding of the mechanisms and strategies for overcoming chemo resistance can greatly improve therapeutic outcomes for patients. In this review article, the bioactive compounds present in Z. Jujube are explained. The high prevalence of many different cancers worldwide has recently attracted the attention of many researchers. This is why our research group focused on studying the anticancer activity of Z. Jujube as well as its impact on chemo resistance both in vivo and in vitro. We hope that these studies can lead to a promising future for cancer patients. 

Angiotensin-II receptor blocker losartan, approved by the FDA in 1995, is used to treat hypertension, diabetic nephropathy, and to lower the risk of stroke. A considerable increase in the risks of heart, brain, kidney diseases is caused by hypertension, sometimes known as the "silent killer," which is the first world's largest cause of premature death. Adults in low- and middle-income countries who are between the ages of 30-79 are affected by hypertension, with the number of cases rising from 650 million to 1.28 billion during the past 30 years. Because it could not have any symptoms or warning indications, 46% of adults are unaware of it. Matrix tablets of Losartan potassium as Systems for delivering drugs with a sustained release are intended to prolong the therapeutic effect of a drug after it has been administered in a single dose. Hydrophobic and hydrophilic matrices have been utilized for polymeric matrices in matrix tablets, which regulate the drug's release and have different solubility qualities. Designing and characterizing tablets with a sustained release of losartan potassium are the goals of the current work. Matrix tablets containing 50 mg losartan were developed using 3 different polymers; HPMC-K4, HPMC-K15 &synthetic Ethyl Cellulose (EC) with sodium alginate in different drug polymer ratios (30, 40, 50 mg) respectively. According to the study, the formulation S3 using (HPMC-K4: Sodium alginate as in 50:50 ratio) demonstrated sustained drug release at a rate of 95.1% and displayed the greatest swelling index when compared to other formulations. 

Tamarind is a nutritious fruit with a variety of uses. The properties of this species have been extensively studied, particularly with reference to the components of the whole parts. Tamarind has many valuable properties and virtually every part of the tree has been utilised by both rural and urban dwellers. Microscopically root powder showed the presence of different structures, Physicochemical parameters including foreign matter, total ash value, acid insoluble ash, etc were evaluated. Phytochemical screening showed the presence of primary and secondary metabolites. All these parameters will help in confirming identity, quality, purity and efficacy of the root. With the help of phytochemical analysis, the drug is understood to have many therapeutic applications, there is a wide scope for its clinical trial.