Coronaviruses can cause illness in people all around the world. They typically cause respiratory infections ranging from the common cold to more serious diseases like middleeast respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS), and infectious disease. Molnupiravir is the first orally available medicine to immediately inhibit SARS-CoV-2 and has the potential to be used for treatment of covid 19. Molnupiravir has a high safety profile, tolerability, and oral bioavailability in humans. Molnupiravir may be available in a patient-friendly oral dose form in the first or second quarter of 2022. Early treatment with molnupiravir lowered the risk of hospitalization or death. Various antiviral drugs that are used for COVID-19 treatment are given in this review. We have also explained the various studies related to molnupiravir that could help researchersin finding the effectiveness of molnupiravir. 

Solubility is one of the major parameter to obtain desired concentration of drug in systemic circulation for pharmacological response to be displayed. Drug efficiency is directly proportional to the solubility of a drug. Poor solubility of a drug leads to low dissolution rate and is followed by low absorption of the drug in the gastro intestinal tract when administered orally. Around 40% of all new chemical entity shows poor bioavailability. Enhancing the bioavailability of poorly soluble drugs can be one of the biggest challenges for formulation scientists in the upcoming years. Molecules that would have highly beneficial effect on their physiological target would not be further developed if their bioavailability is limited by their solubility in water. Aqueous solubility of drug also affects physical, chemical properties of the drug, dose, stability in gastrointestinal track, severs as standard for test of purity, the rate of dissolution of solid, rate and extent of absorption, achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Thus solubility is a most important concept presenting itself as valuable contributor in the formulation of pharmaceuticals. The purpose of this review is to discuss the various solubility enhancement technique like chemical modification which includes salt formation, co-crystallization, co-solvency, hydrotrophy, nanotechnology etc and physical modification includes particle size reduction, complexation, surfactants, solid dispersions etc and pH adjustment, supercritical fluid process, liquisolid technique, polymeric alteration. These technologies enhance the solubility of the drugs and thus allows to make the formulations in different dosage forms efficiently and thus enhances the dissolution and bioavailability of the drug.Solubility is one of the major parameter to obtain desired concentration of drug in systemic circulation for pharmacological response to be displayed. Drug efficiency is directly proportional to the solubility of a drug. Poor solubility of a drug leads to low dissolution rate and is followed by low absorption of the drug in the gastro intestinal tract when administered orally. Around 40% of all new chemical entity shows poor bioavailability. Enhancing the bioavailability of poorly soluble drugs can be one of the biggest challenges for formulation scientists in the upcoming years. Molecules that would have highly beneficial effect on their physiological target would not be further developed if their bioavailability is limited by their solubility in water. Aqueous solubility of drug also affects physical, chemical properties of the drug, dose, stability in gastrointestinal track, severs as standard for test of purity, the rate of dissolution of solid, rate and extent of absorption, achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Thus solubility is a most important concept presenting itself as valuable contributor in the formulation of pharmaceuticals. The purpose of this review is to discuss the various solubility enhancement technique like chemical modification which includes salt formation, co-crystallization, co-solvency, hydrotrophy, nanotechnology etc and physical modification includes particle size reduction, complexation, surfactants, solid dispersions etc and pH adjustment, supercritical fluid process, liquisolid technique, polymeric alteration. These technologies enhance the solubility of the drugs and thus allows to make the formulations in different dosage forms efficiently and thus enhances the dissolution and bioavailability of the drug.Solubility is one of the major parameter to obtain desired concentration of drug in systemic circulation for pharmacological response to be displayed. Drug efficiency is directly proportional to the solubility of a drug. Poor solubility of a drug leads to low dissolution rate and is followed by low absorption of the drug in the gastro intestinal tract when administered orally. Around 40% of all new chemical entity shows poor bioavailability. Enhancing the bioavailability of poorly soluble drugs can be one of the biggest challenges for formulation scientists in the upcoming years. Molecules that would have highly beneficial effect on their physiological target would not be further developed if their bioavailability is limited by their solubility in water. Aqueous solubility of drug also affects physical, chemical properties of the drug, dose, stability in gastrointestinal track, severs as standard for test of purity, the rate of dissolution of solid, rate and extent of absorption, achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Thus solubility is a most important concept presenting itself as valuable contributor in the formulation of pharmaceuticals. The purpose of this review is to discuss the various solubility enhancement technique like chemical modification which includes salt formation, co-crystallization, co-solvency, hydrotrophy, nanotechnology etc and physical modification includes particle size reduction, complexation, surfactants, solid dispersions etc and pH adjustment, supercritical fluid process, liquisolid technique, polymeric alteration. These technologies enhance the solubility of the drugs and thus allows to make the formulations in different dosage forms efficiently and thus enhances the dissolution and bioavailability of the drug.Solubility is one of the major parameter to obtain desired concentration of drug in systemic circulation for pharmacological response to be displayed. Drug efficiency is directly proportional to the solubility of a drug. Poor solubility of a drug leads to low dissolution rate and is followed by low absorption of the drug in the gastro intestinal tract when administered orally. Around 40% of all new chemical entity shows poor bioavailability. Enhancing the bioavailability of poorly soluble drugs can be one of the biggest challenges for formulation scientists in the upcoming years. Molecules that would have highly beneficial effect on their physiological target would not be further developed if their bioavailability is limited by their solubility in water. Aqueous solubility of drug also affects physical, chemical properties of the drug, dose, stability in gastrointestinal track, severs as standard for test of purity, the rate of dissolution of solid, rate and extent of absorption, achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Thus solubility is a most important concept presenting itself as valuable contributor in the formulation of pharmaceuticals. The purpose of this review is to discuss the various solubility enhancement technique like chemical modification which includes salt formation, co-crystallization, co-solvency, hydrotrophy, nanotechnology etc and physical modification includes particle size reduction, complexation, surfactants, solid dispersions etc and pH adjustment, supercritical fluid process, liquisolid technique, polymeric alteration. These technologies enhance the solubility of the drugs and thus allows to make the formulations in different dosage forms efficiently and thus enhances the dissolution and bioavailability of the drug.Solubility is one of the major parameter to obtain desired concentration of drug in systemic circulation for pharmacological response to be displayed. Drug efficiency is directly proportional to the solubility of a drug. Poor solubility of a drug leads to low dissolution rate and is followed by low absorption of the drug in the gastro intestinal tract when administered orally. Around 40% of all new chemical entity shows poor bioavailability. Enhancing the bioavailability of poorly soluble drugs can be one of the biggest challenges for formulation scientists in the upcoming years. Molecules that would have highly beneficial effect on their physiological target would not be further developed if their bioavailability is limited by their solubility in water. Aqueous solubility of drug also affects physical, chemical properties of the drug, dose, stability in gastrointestinal track, severs as standard for test of purity, the rate of dissolution of solid, rate and extent of absorption, achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Thus solubility is a most important concept presenting itself as valuable contributor in the formulation of pharmaceuticals. The purpose of this review is to discuss the various solubility enhancement technique like chemical modification which includes salt formation, co-crystallization, co-solvency, hydrotrophy, nanotechnology etc and physical modification includes particle size reduction, complexation, surfactants, solid dispersions etc and pH adjustment, supercritical fluid process, liquisolid technique, polymeric alteration. These technologies enhance the solubility of the drugs and thus allows to make the formulations in different dosage forms efficiently and thus enhances the dissolution and bioavailability of the drug.Solubility is one of the major parameter to obtain desired concentration of drug in systemic circulation for pharmacological response to be displayed. Drug efficiency is directly proportional to the solubility of a drug. Poor solubility of a drug leads to low dissolution rate and is followed by low absorption of the drug in the gastro intestinal tract when administered orally. Around 40% of all new chemical entity shows poor bioavailability. Enhancing the bioavailability of poorly soluble drugs can be one of the biggest challenges for formulation scientists in the upcoming years. Molecules that would have highly beneficial effect on their physiological target would not be further developed if their bioavailability is limited by their solubility in water. Aqueous solubility of drug also affects physical, chemical properties of the drug, dose, stability in gastrointestinal track, severs as standard for test of purity, the rate of dissolution of solid, rate and extent of absorption, achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Thus solubility is a most important concept presenting itself as valuable contributor in the formulation of pharmaceuticals. The purpose of this review is to discuss the various solubility enhancement technique like chemical modification which includes salt formation, co-crystallization, co-solvency, hydrotrophy, nanotechnology etc and physical modification includes particle size reduction, complexation, surfactants, solid dispersions etc and pH adjustment, supercritical fluid process, liquisolid technique, polymeric alteration. These technologies enhance the solubility of the drugs and thus allows to make the formulations in different dosage forms efficiently and thus enhances the dissolution and bioavailability of the drug. 

The antioxidant activity of a hydroalcoholic extract of polyherbal mixture (RVMP) using four different herbs, namely Rubia cordifolia, Vitex negundo, Piper nigrum, and Myristica fragrans, was determined in this study using 1,1-diphenyl-2-picrylhydrazyl (DPPH), reducing power assay, hydroxyl radical scavenging assay, and nitric oxide scavenging assay (NO).The findings show that polyherbal mixture (RVMP) has significant antioxidant activity. The total phenolic content and flavanoids were also ascertained. The polyherbal mixture contained a significant amount of phenolic content. The current study's antioxidant activity data suggest that polyherbal mixture (RVMP) is a superior source of natural antioxidants, which may aid in the prevention of oxidative stress progression.The antioxidant activity of a hydroalcoholic extract of polyherbal mixture (RVMP) using four different herbs, namely Rubia cordifolia, Vitex negundo, Piper nigrum, and Myristica fragrans, was determined in this study using 1,1-diphenyl-2-picrylhydrazyl (DPPH), reducing power assay, hydroxyl radical scavenging assay, and nitric oxide scavenging assay (NO).The findings show that polyherbal mixture (RVMP) has significant antioxidant activity. The total phenolic content and flavanoids were also ascertained. The polyherbal mixture contained a significant amount of phenolic content. The current study's antioxidant activity data suggest that polyherbal mixture (RVMP) is a superior source of natural antioxidants, which may aid in the prevention of oxidative stress progression. 

Menopause is most significant event for a woman life, carrying with it a slew of physiological changes with long-term consequences for her life. Although is transition to menopause has uncertain physiology and clinical symptoms. There are suggested there are causal relationships between menopause and a variety of manifestations and disorders. The proof for these links is changed and examined. There have been numerous theories about the symptoms that arise before, during, and after menopause. Hormone Replacement Therapy (HRT) is frequently used to treat symptoms of estrogen withdrawal, including dyspareunia, hot flushes, vaginal dryness, night sweats, insomnia, however, it has not been demonstrated to help with depression or arthritis in middle age. Hormone replacement therapy doses and routes differ depending on the indication. Hormone replacement therapy complications vary depending on the regimen utilized. This article will describe these symptoms, as well as the underlying pathophysiology and treatment alternatives. 

The present research work deals with the formulation and evaluation of herbal cream against acne vulgaris. The herbals are having the worldwide market now- a-days. The ethanolic extracts of eucalyptus (leaves) and aloevera (leaves) were formulated into a cream. The plants are having good anti- microbial, and Anti inflammatory according to the literature survey. Seven batches of o/w herbal cream was formulated and named as F1-F7. These formulations are evaluated according to physicochemical properties and also the study includes microscopical and macroscopical evaluations. The prepared formulation was optimized by in vitro release study.The cream,s effectiveness is compared to that of a commercially available acne treatment product.