IAJPR

Indo American Journal of Pharmaceutical Research

ISSN NO.: 2231-6876
OCTOBER 2023
1

A COMPARATIVE STUDY ON THE EFFECT OF ANTIBIOTICS ON THE RENAL PROFILE OF PATIENTS WITH DIABETES MELLITUS

Rashmi Ahmed, Karabi Das*, Manashi Garg, Sahil Hasan Choudhury, Bhabana Garg

Department of Medical Laboratory Technology, GEA National College.

Diabetes mellitus is one of the leading causes of mortality and morbidity in modern life. Diabetes mellitus have many complication later on in life i.e., diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, these are the most common complications of diabetes. Nowadays case of injudicious use of antibiotics is increasing day by day. Therefore our study present with the effect of antibiotics in the renal profile of the patient with diabetes mellitus.A total of 80 blood and urine sampleseach were collected from diabetic patient and tested in automated analyser and dipstick method. Out of 80 samples from the diabetic patient, 22 patients were taking antibiotics and rest 58 were not taking antibiotics. Out of 22 antibiotic intake patients, 14 diabetic patients have deranged renal profile along with abnormal GFR. Antibiotic used in diabetes mellitus leads to derangement of renal profile. The above findings shows the adverse effects of using antibiotics for treating infections in diabetic patients. 


 


2

A PHARMACOGNOSTICAL STUDY OF BIDALI- Dioscorea pentaphylla Linn.

Dr. Akshatha Somayaji K1*, Dr. Giri Prashanth K.G.2, Dr. Shiva Manjunath M.P.3, Dr. Suresh Janadri4, Dr. Seema Pradeep5

Sri Sri College of ayurvedic Science and Research, 21st KM Kanakapura Road, Udayapura Post, Bengaluru-560082.

The ancient life science of India – Ayurveda, enumerates an extensive list of herbal medicines across its treatises, out of which many are not included in the Ayurvedic Pharmacopoeia of India. One among these plants is Bidali, and Dioscorea pentaphylla Linn.is the botanical source, belonging to Dioscoreaceae family. It is commonly known as Yam or Five leaf yam, which is used as staple food and to cure many health ailments by the tribals. The tubers of Bidali- Dioscorea pentaphylla Linn. was collected from Devarayana Durga, Savana Durga (Tumkuru), Perdooru (Udupi), and Badamanavaratekaval (Bengaluru). Pharmacognostical studies like Macroscopic, Microscopic, Organoleptic, Physico-chemical, Preliminary Qualitative Phytochemical Analysis and Quantitative Phytochemical Analysis were carried out. The results of preliminary qualitative phytochemical analysis revealed the presence of Alkaloids, Steroids, Carbohydrates, Starch, Protein, Tannins, Phenols, Flavonoids, Saponins. Quantitative phytochemical analysis showed the presence of Flavones and Saponins in higher concentration which indicates the therapeutic probabilities. 


 


3

FORMULATION AND EVALUATION OF POLY HERBAL SOAP

G. Sai Manoj, D. Varaprada, K. Abesana Chanu, M. Ritheesh, K. Blessi Priyanka*

University College of Pharmaceutical Sciences, Kakatiya University, Warangal- 506009.

Plants with medicinal properties are being used as traditional medicine from times immemorial. The extract obtained from the leaves, stem and roots of various medicinal plants have been employed as a natural remedy in curing various ailments and diseases. The aim of the present study is to formulate herbal soap containing Vigna radiate, aloe vera, tomato juice and further subjected to physicochemical characterizations such as color, odor, texture, foam height, foam retention, irritation, saponification value and pH. The main ingredient, moong dal (Vigna radiata), commonly known as green gram, has therapeutic qualities. Moong dal, is excellent for oily and acne-prone skin for beutification purpose. Green gram eliminates dangerous bacteria, removes dirt and excess oil, leaving the skin clear, supple and free of wrinkles. The antibacterial activity of the formulated soap was checked in agar diffusion method and it shows moderate active against the S. aureus and E.coli. The results show that the soap possesses moderate antimicrobial activity. The objective of this study is to formulate poly herbal soap for the beautification purpose. Hence, this study is concluded as the formulated poly herbal soap can be used as for the cleansing and beautification purpose. 


 


4

EVALUATION OF ANTI-OBESITY EFFECT OF SUGOLESS, A NEW POLYHERBAL FORMULATION IN PROGESTERONE INDUCED OBESITY IN MICE

Gourav Ganguly, Arabinda Nayak*

Gupta College of Technological Sciences, Asansol, West Bengal, India.

Sugoless is a natural formulation used for its anti-diabetic properties. It is an herbal medicine for the control of blood sugar.The aim of the study is?Evaluation of Anti-obesity Effect of Sugoless, A New Polyherbal Formulation in Progesterone Induced Obesity in Mice’’.The extracts were prepared by maceration method. Anti-obesity activity was evaluated by different parameters like Food intake, Bodyweight, organ weight & relative organ weight, Exploratory behavior, Biochemical estimations & Histopathological examinations. After performing the experiment, it has been concluded that the sugoless formulation has anti-obesity properties, sugoless formulation of 1480 mg/kg showed better activity than 740 mg/kg and 370 mg/kg (p <0.05). 


 


5

URSODEOXYCHOLIC ACID: REMARKABLE DERIVATIVE AS LIVER PROTECTANT

Tushar Nehere, Purva Kolhe, Revati Khawale, Snehal Chakorkar*

Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.

Ursodeoxycholic acid is a choleretic. Ursodeoxycholic acid responsible for raising bile production in body and ultimately bile is necessary for the breakdown of lipids. Additionally, bile is responsible for removal body's toxin. In addition to its choleretic effect, ursodeoxycholic acid also has anti-inflammatory and antioxidant properties. This characteristic may help in preventing liver injury and promoting repair. Additionally, ursodeoxycholic acid has been demonstrated to have cytoprotective properties, which implies that it may aid in preventing the death of liver cells. People who have liver problems that cause bile to build up may benefit from ursodeoxycholic acid's ability to increase bile flow. It helps the liver by various complementary mechanisms. It helps the liver by its cytoprotective, Immunomodulatory, and Anti apoptotic. A non-toxic, hydrophilic bile acid called ursodeoxycholic acid (ursodiol) is used mostly to treat cholestatic liver diseases. It improves the biochemical parameters in various diseases and widely used in treatment of Primary biliary cirrhosis, Primary sclerosing cholangitis, Intrahepatic cholestasis of pregnancy, Cystic fibrosis, but furthermore studies are need to be done in clinical uses. The only medication authorized for use as the first-line treatment for PBC is ursodeoxycholic acid (UCDA). Overall, ursodeoxycholic acid is a potent molecule with a wide range of beneficial effects on the liver. The ability of ursodeoxycholic acid to treat various liver conditions, including alcoholic liver disease and hepatitis C, is currently being researched. This review summarizes the current understanding of the ursodeoxycholic acid mechanisms of action and offers data from clinical studies on its application to chronic liver disorders.