Abstract

The demand for mouth dissolving tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. The purpose of this research was to mask the intensely bitter taste of Ondansetron HCl and to formulate an orodispersible of the taste-masked drug. Taste masking was done by complexing Ondansetron HCl with different resins like Tulsion 335, Indion 254, Kyron T134, and Doshion P 514 in different ratio 1:1, 1:2 and 1:3 (% w/w) with solvent evaporation method and evaluated by physical and chemical method. Further DRC formulated as oral dispersible tablets and evaluated for patient palatability & disintegration time.

Abstract

A fast, robust RP-HPLC method was developed for simultaneous determination of Bisoprolol fumarate and Amlodipine besylate in tablets. The mobile phase was mixture of Methanol: Acetonitrile: 50mM Potassium dihydrogen phosphate buffer KH2PO4 (25:30:45 v/v) at pH 3.0 at 1 ml/min. The stationary phase was C18Intersil 4.6 x 150 mm (id). UV detection was performed at 267 nm.

ABSTRACT

Substituted 2-phenylbenzo[d]thiazoles were synthesized by stirring a mixture of aldehyde and 2-aminothiol in CH2Cl2 at room temperature using Phenyltrimethylammonium tribromide as a catalyst. We show here that Phenyltrimethylammonium tribromide, a stable, crystalline organic ammonium tribromide, can be readily utilized as an alternative electrophilic bromine source. It is easier to control the stoichiometry of addition with an organic ammonium tribromide, which minimizes aromatic bromination caused by excess reagent. It brings about the efficient oxidative cyclization of benzaldehydes and 2- aminothiols to the corresponding benzothiazoles under mild conditions via condensation.

Abstract

The present investigation concerns the development of Sustained release
matrix tablets of Captopril, which after oral administration are designed to
prolong the duration up to 12 hrs and thereby increase patient compliance,
reduced frequency of administration and increase therapeutic efficacy. Ten
batches of tablets were fabricated containing Captopril, polymers HPMC
K100M, ethyl cellulose, sodium CMC and other excipients. All the batches
were formulated by direct compression. The evaluation was done on the
granules which include compressibility, flow property. The tablets were
evaluated for appearance, thickness, hardness, assay, weight variation,
friability, and in vitro release studies. The results obtained were satisfactory
and complies with the Pharmacopoeial specifications. The formulation
containing HPMC K100M and ethyl cellulose (F7) showed slower release
as compare to other formulations. The in-vitro release data was treated with
mathematical equations. Thus the combination of HPMC K100M and ethyl
cellulose (1:1) shows satisfactory retarding release of Captopril from matrix
to 12 hrs.

Amlodipine besylate is a recognized drug for hypertension therefore development of an
ODT of Amlodipine besylate and to evaluate the effect of various superdisintegrants on its
disintegration time and release profile was the prime objective of this research work.
Tablets were prepared by direct compression technique using three different
superdisintegrants. Sodium starch glycolate, Croscarmellose sodium and Crosspovidone
XL-10 were used as superdisintegrants in combinations to achieve optimum release profile,
disintegration time and hardness. Direct compression process was selected for this
formulation of ODT tablets, because porous nature is more in direct compression blend
than wet granulation blend, so it will give faster disintegration. Microcrystalline cellulose
was used as diluent and mannitol, mint flavor and sodium saccharin were used to enhance
the organoleptic properties of tablets. The tablets were evaluated for weight variation,
hardness, friability, in-vitro disintegration time and drug release characteristics. Hardness
and friability data indicated good mechanical strength around 3 kg/cm2 for all the batches.
The results of in-vitro disintegration time indicated that the tablets dispersed rapidly in
mouth within 60s. Dissolution study revealed release rate of drug from the tablets was
comparable with marketed tablet formulation of Amlodipine besylate. It was concluded
that superdisintegrants addition technique is a useful method for preparing orally
disintegrating tablets by direct compression method.

Spray drying is a technique which has a wide range of applications in the pharmaceutical
industry. The unique possibilities for particle engineering, potent drug handling and
continuous production makes spray drying the preferred tool in formulation departments in
more and more companies. The present review highlights the instrumentation, advantages
and the various applications of spray drying. 

Loperamide HCL is an opioid receptor agonist and acts on the mu
opioid receptors in the myenteric plexus large intestines; it works
specifically by decreasing the activity of the myenteric plexus which
decreases the motility of the circular and longitudinal smooth
muscles of the intestinal wall. Loperamide HCL is a synthetic antidiarrheal
indicated for the control and symptomatic relief of acute
nonspecific diarrhea and of chronic diarrhea associated with
inflammatory bowel disease. Loperamide HCl, fast dissolving tablets
have been prepared by direct compression method by using kneading
mixture of Loperamide HCl and Crospovidone, after incorporating
superdisintegrants such as Ac-di sol, Sodium starch glycolate, in
different concentrations. All the formulation were evaluated for the
influence of disintegrants and their concentrations on the
characteristics of fast dissolving tablets mainly in terms of
disintegration time and dissolution rate. Tablets containing Ac-di-sol
at high concentration showed better disintegration character (10
seconds) along with rapid release (97.3%). The concentration of the
superdisintegrants had also an effect on disintegration time and invitro
dissolution. The resulting tablets were also evaluated for its
hardness, thickness, wetting time and water absorption ratio.

The objective of the present study was to incorporate poorly soluble Aceclofenac (ACF)
into microemulsion based formulation. In present study microemulsion was prepared with
6% w/w Isopropyl Myristate (IPM), 27%w/w Tween 80 & 18%w/w PEG-400 as oil,
surfactant & Cosurfactant respectively. The ratio of surfactant: cosurfactant was fixed at
4:1 on the basis of Ternary phase diagram. Microemulsion gel was prepared using 1%
Carbopol 934 as a gelling agent. Optimized formulation was evaluated for drug content,
zeta potential, droplet size, drug assay, pH, viscosity, in-vitro drug release profile and
stability study. Globule size of optimize batch ACF 5 was found to be 11.52 ± 0.6 nm. In
vitro release study had shown 25.55 ± 2.39 % drug release from microemulsion gel which
was more compared to marketed product. Optimize batch ACF 5 was found stable
throughout stability study for two months at different temperature (2-8°c & room
temperature).