Indo American Journal of Pharmaceutical Research

ISSN NO.: 2231-6876
June 2011

Formulation and evaluation of taste masked oral disintegrating tablet of ondansetron hydrochloride

Alpesh Brahmbhatt*1, A.K Seth1, Suri Babu Jammula 2, Tejas Ghelani 1, Gajanan Deshmukh1, Nirmal Shah1, Sharad Kumar1
1Department of Pharmacy, Sumandeep Vidhyapeeth University, Piparia, Ta. Waghodia, Vadodara, Gujarat.
2Cadila Pharmaceutical Ltd, Dholka, Ahmedabad, Gujarat.


The demand for mouth dissolving tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. The purpose of this research was to mask the intensely bitter taste of Ondansetron HCl and to formulate an orodispersible of the taste-masked drug. Taste masking was done by complexing Ondansetron HCl with different resins like Tulsion 335, Indion 254, Kyron T134, and Doshion P 514 in different ratio 1:1, 1:2 and 1:3 (% w/w) with solvent evaporation method and evaluated by physical and chemical method. Further DRC formulated as oral dispersible tablets and evaluated for patient palatability & disintegration time.


Spray Drying in the Pharmaceutical Industry - A Review

C.J.Aundhia1*, J A.Raval2, M.M.Patel3, N.V Shah1, S.P.Chauhan1, G.U.Sailor1, A.R.Javia1, R.A.Mahashwari1
1Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat 391670, India.
2S.K. Patel College of Pharmaceutical Education and Research, Mehsana-Gozaria highway, Kherva, Mehsana, Gujarat 382711,


Spray drying is a technique which has a wide range of applications in the pharmaceutical industry. The unique possibilities for particle engineering, potent drug handling and continuous production makes spray drying the preferred tool in formulation departments in more and more companies. The present review highlights the instrumentation, advantages and the various applications of spray drying.


Formulation Development and Evaluation of Fast Dissolving Tablet Loperamide HCl

Erande Ritesh1*, T. Regupathi1, Shaikh Surfraj1., Baokar Shrikrishna2
1Department of Pharmaceutics, Ultra College of Pharmacy, Thasildar Nagar, Madurai, Tamilnadu, India
2 Department of Pharmaceutical Chemistry. SVPM’S college of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist-Pune,
Maharashtra, India


Loperamide HCL is an opioid receptor agonist and acts on the muopioid receptors in the myenteric plexus large intestines; it works specifically by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall. Loperamide HCL is a synthetic antidiarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Loperamide HCl, fast dissolving tablets have been prepared by direct compression method by using kneading mixture of Loperamide HCl and Crospovidone, after incorporating superdisintegrants such as Ac-di sol, Sodium starch glycolate, in
different concentrations. All the formulation were evaluated for the influence of disintegrants and their concentrations on the characteristics of fast dissolving tablets mainly in terms of disintegration time and dissolution rate. Tablets containing Ac-di-sol at high concentration showed better disintegration character (10 seconds) along with rapid release (97.3%). The concentration of the superdisintegrants had also an effect on disintegration time and invitro dissolution. The resulting tablets were also evaluated for itshardness, thickness, wetting time and water absorption ratio.


Analytical Method Development and Validation for Simultaneous Determination of Bisoprolol Fumarate and Amlodipine Besylate

Shrikrishna B.Baokar*, Ritesh S. Erande, Surfraj G.Shaikh
Department Of Pharmaceutical Chemistry, SVPM’s College of Pharmacy, Malegaon (BKII), Tal-Baramati, Dist-Pune,
Maharashtra, India-411513


A fast, robust RP-HPLC method was developed for simultaneous determination of Bisoprolol fumarate and Amlodipine besylate in tablets. The mobile phase was mixture of Methanol: Acetonitrile: 50mM Potassium dihydrogen phosphate buffer KH2PO4 (25:30:45 v/v) at pH 3.0 at 1 ml/min. The stationary phase was C18Intersil 4.6 x 150 mm (id). UV detection was performed at 267 nm.


One Pot Synthesis of Substituted Benzothiazoles from substituted aldehydes and 2-aminothiols using Phenyltrimethylammonium tribromide

S. P. Hangirgekar* and S. G. Shirodkar
1*School of Chemical Sciences, Swami Ramanad Teerth Marathwada University, Nanded-431606, Maharashtra,


Substituted 2-phenylbenzo[d]thiazoles were synthesized by stirring a mixture of aldehyde and 2-aminothiol in CH2Cl2 at room temperature using Phenyltrimethylammonium tribromide as a catalyst. We show here that Phenyltrimethylammonium tribromide, a stable, crystalline organic ammonium tribromide, can be readily utilized as an alternative electrophilic bromine source. It is easier to control the stoichiometry of addition with an organic ammonium tribromide, which minimizes aromatic bromination caused by excess reagent. It brings about the efficient oxidative cyclization of benzaldehydes and 2- aminothiols to the corresponding benzothiazoles under mild conditions via condensation.


Preliminary phytochemical screening, acute toxicity study and anti-inflammatory activity of Pitta sura kudineer

S. Balachandar*1, R. Nandini1, V. Rajalakshimi1, J. Esther Jayasheela1, P. Sathiyarajeswaran2
1Institute of Pharmacology, Madras Medical College, Chennai, TN, India.
2Central Research Institute for Siddha, Chennai, TN, India.


The ethanolic extract of the aerial parts and roots of Pitta sura kudineer formulation was subjected to preliminary phytochemical screening, acute toxicity and anti-inflammatory studies. Phytochemical screening of the extract revealed the presence of alkaloids, flavonoids, tannins, steroids, gums, and reducing sugars. Acute toxicity study is carried out according to Organization for Economic Cooperation and Development guideline-423
(OECD) for 14 days. The result of acute toxicity studies (2000 mg/kg b.w.) showed no alteration in the general behavior of animals and showed no mortality and found to be safe. Based on the acute toxicity study, two doses were fixed to be 200 mg/kg and 400 mg/kg b.w. and used for further studies. Anti-inflammatory study of ethanolic extract was investigated at doses 200 mg/kg and 400 mg/kg b.w. by using carrageenan-induced paw
edema in vivo screening method. Oral administration of ethanolic extract produced significant (P<0.01) decrease in paw edema volume induced by carrageenan. The present study highlighted the anti-inflammatory activity and demonstrated that Pitta sura kudineer has significant anti-inflammatory activity, and also it justifies the traditional use of this formulation in the treatment of various types of pain and inflammation.



Pankit Mehta*1, Gajanan.J.Deshmukh1, A.K.Seth 1, Patel Banty2
1Department of Pharmacy, Sumandeep Vidyapeeth University, Vadodara-391760, Gujarat, India
2Shri Sarvajanik Pharmacy College, GTU, Mehsana-384001, Gujarat, India


The present investigation concerns the development of Sustained release
matrix tablets of Captopril, which after oral administration are designed to
prolong the duration up to 12 hrs and thereby increase patient compliance,
reduced frequency of administration and increase therapeutic efficacy. Ten
batches of tablets were fabricated containing Captopril, polymers HPMC
K100M, ethyl cellulose, sodium CMC and other excipients. All the batches
were formulated by direct compression. The evaluation was done on the
granules which include compressibility, flow property. The tablets were
evaluated for appearance, thickness, hardness, assay, weight variation,
friability, and in vitro release studies. The results obtained were satisfactory
and complies with the Pharmacopoeial specifications. The formulation
containing HPMC K100M and ethyl cellulose (F7) showed slower release
as compare to other formulations. The in-vitro release data was treated with
mathematical equations. Thus the combination of HPMC K100M and ethyl
cellulose (1:1) shows satisfactory retarding release of Captopril from matrix
to 12 hrs.


Formulation and Evaluation of Amlodipine besylate orally disintegrating tablet

Nirav V. Patel, Sachin Chauhan, Chintan Aundhia, A. K. Seth
Department of Pharmacy, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.


Amlodipine besylate is a recognized drug for hypertension therefore development of an ODT of Amlodipine besylate and to evaluate the effect of various superdisintegrants on its disintegration time and release profile was the prime objective of this research work. Tablets were prepared by direct compression technique using three different superdisintegrants. Sodium starch glycolate, Croscarmellose sodium and Crosspovidone XL-10 were used as superdisintegrants in combinations to achieve optimum release profile, disintegration time and hardness. Direct compression process was selected for this formulation of ODT tablets, because porous nature is more in direct compression blend than wet granulation blend, so it will give faster disintegration. Microcrystalline cellulose was used as diluent and mannitol, mint flavor and sodium saccharin were used to enhance the organoleptic properties of tablets. The tablets were evaluated for weight variation, hardness, friability, in-vitro disintegration time and drug release characteristics. Hardness and friability data indicated good mechanical strength around 3 kg/cm2 for all the batches. The results of in-vitro disintegration time indicated that the tablets dispersed rapidly in mouth within 60s. Dissolution study revealed release rate of drug from the tablets was comparable with marketed tablet formulation of Amlodipine besylate. It was concluded that superdisintegrants addition technique is a useful method for preparing orally disintegrating tablets by direct compression method.


Development and characterization of Microemulsion based system of Aceclofenac

N.V.Shah*1, T.K Ghelani1, Vipin Saini2, U.T. Joshi1, A.K.seth1, S.P.Chauhan1, C.J.Aundhia1, R .A. Maheshwari1
1Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara - 391760, Gujarat, India.2MJRP University, Jaipur, Rajasthan, India.


The objective of the present study was to incorporate poorly soluble Aceclofenac (ACF)
into microemulsion based formulation. In present study microemulsion was prepared with
6% w/w Isopropyl Myristate (IPM), 27%w/w Tween 80 & 18%w/w PEG-400 as oil,
surfactant & Cosurfactant respectively. The ratio of surfactant: cosurfactant was fixed at
4:1 on the basis of Ternary phase diagram. Microemulsion gel was prepared using 1%
Carbopol 934 as a gelling agent. Optimized formulation was evaluated for drug content,
zeta potential, droplet size, drug assay, pH, viscosity, in-vitro drug release profile and
stability study. Globule size of optimize batch ACF 5 was found to be 11.52 ± 0.6 nm. In
vitro release study had shown 25.55 ± 2.39 % drug release from microemulsion gel which
was more compared to marketed product. Optimize batch ACF 5 was found stable
throughout stability study for two months at different temperature (2-8°c & room