Abstract
In the present work an attempt has been made to prepare Ranolazine extended release tablets where polymers were blended with the drug and excipients. The compatibility determined by FTIR and about nine different formulations were developed by wet granulation method. Formulation F9 containing 500mg of drug contains Micro Crystalline Cellulose, Carbopol 940, Hydroxyl Propyl Methyl Cellulose and opadry orange as the film coater released 99% of drug at 24hrs of time intervals under different media like 0.1HCl and phosphate buffer(7.4) and release followed zero order kinetics. All tablets were good fit for Higuchi plot (R2=0.99) therefore diffusion mechanism was found and superimposable with the market product RANEXA. Accelerated stability studies conducted at 400c/75%RH for three months as per ICH guidelines.
