Epilepsy
is a prevalent neurological disorder characterized by recurrent, unprovoked
seizures, affecting approximately 50 million people globally. Although
antiepileptic drugs (AEDs) are the primary treatment, around 30% of patients
remain resistant to current therapies, and many experience adverse effects that
compromise their quality of life. These limitations have driven interest in
alternative approaches, particularly Phytotherapy, which utilizes medicinal
plants rich in bioactive compounds with therapeutic potential.Phytotherapy
offers a promising, safer alternative for epilepsy management, owing to its
multifaceted mechanisms and lower toxicity profiles. This review explores the
antiepileptic potential of Clerodendrum phlomidis and Stephania
glabra, two medicinal plants traditionally used in neurological disorders.
Both species contain diverse phytochemicals, including alkaloids, flavonoids,
and terpenoids, known for their neuroprotective, antioxidant, and
anticonvulsant properties. Experimental studies suggest these plants may
modulate neurotransmission, enhance GABAergic activity, and reduce seizure
frequency.Given the need for novel and effective antiepileptic therapies,
plant-based treatments represent a valuable area of research. This review
highlights the relevance of C. phlomidis and S. glabra in
Phytotherapy and emphasizes the importance of further pharmacological and
clinical studies to validate their efficacy and safety in epilepsy treatment.
