The objective of present study was to document the requirements for manufacturing of semisolid dosage forms. These guidelines also brief about some issues associated with tools, strategies, critical process parameters and strategies of the manufacturing and validation processes specific to semisolid dosage forms. Studies about the effect of manufacturing processes and formulation exipients on the rheology of semisolids have contributed significantly toward their characterization. The development of computer-assisted instruments also has contributed substantially to their characterization and thereby to improving their quality. Variations in the manufacturing procedure that occur after either of these events are likely to be critical to the characteristics of the finished product. This is especially true of any process intended to increase the degree of dispersion through reducing droplet or particle size (e.g., homogenization). Semisolids can adhere to the application surface for sufficiently long periods before they are washed off. This property helps prolong drug delivery at the application site. Novel semisolids are non-greasy since they are made up of water washable bases. Hence they cause less irritation to skin and are superior to conventional semisolid dosage form. The major conclusion drawn from such detailed study of semisolids in –process shortfalls provides a better vision and encounter while designing and developing new formulations.