Welcome to Indo American Journal of Pharmaceutical Research

DECEMBER 2017

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights Download PDF (57) Google Scholar

A STUDY OF PATTERN OF REFERRALS IN LIAISON PSYCHIATRY

Dr Sally John^1*,Dr.Amrita Singam², Dr Sonia Mary Thomas³
¹Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi ,Wardha, Maharashtra Pin 442 001.
²Indira Gandhi Govt. Medical College, Department.of Pharmacology, Nagpur.
³Santhula Trust Hospital, Vadakkara, Oliyapuram P.O Kuthattukulam, Ernakulam Dt, Kerala.

Author Image

Graphical Abstract

Graphical Abstract

Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

Article Highlights Download PDF (8) Google Scholar

Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Shankar P Hangirgekar*, Vijay V Kumbhar,Navanand B Wadwale
School of Chemical Sciences, S.R.T.M.University, Nanded-431606, Maharashtra India.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights Download PDF (11) Google Scholar

PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Dharshini¹, Dr.S.Sumayaa², Dr.T.Thirunalasundari ³

¹Research Scholar, Department of Food Science and Nutrition, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

²Head of the Department, Department of Biotechnology, Bharathidasan University, Tiruchirappali, Tamil Nadu, India.

³Principal, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

Author Image

Graphical Abstract

Graphical Abstract

Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

Article Highlights

The file does not exist in any folder.

Google Scholar

Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ANTIVIRAL DRUGS, GRAZOPREVIR AND ELBASVIR, SIMULTANEOUSLY IN BULK AND IN TABLETS

Pallapati Suman^1,2*, Tirukkovalluri Siva Rao¹, Kallam Venkata Siva Rama Krishna Reddy²
¹Department of Inorganic & Analytical Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India - 530003.
²Laurus Labs Limited, Visakhapatnam, Andhra Pradesh, India - 531021.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

AN IMPACT OF EDUCATIONAL INTERVENTION OF ADVERSE DRUG REACTIONS REPORTING TO AMC-PvPI AMONG NURSES IN TERTIARY CARE TEACHING HOSPITAL

Venkata RamaRao Nallani^*1, Dr.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, Paher University, Udaipur.
⁴Dept of Pharmacology, Guntur Medical College, Guntur.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

CLINICAL PHARMACIST IS KEY ROLE OF THE PATIENT-CENTERED CARE IN TERTIARY CARE TEACHING HOSPITALS IN INDIAN SENERIO

Venkata Ramarao Nallani^*1, Prof.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, PAHER University, Udaipur.

⁴Dept of Pharmacology, Guntur Medical College, Guntur.

Author Image

Graphical Abstract

Graphical Abstract

Pharmacist traditionally involving compounding, production and dispensing of drugs from ancient times. As the diseases and sedentary life style leads to complications to use of more medications to manage the disease and life style problems, this is the time to identify the unsafe and irrationalize medicine medical therapy has emerged. This has also contributed to clinical pharmacists being more involved in patient-centered pharmacotherapy. A large literature documents the multiple roles clinical pharmacists can play in a variety of health care settings. The main aim of the study is role of clinical pharmacist in modifying disease outcome by patient centered care in the medical wards.Clinical pharmacist role between physician and patient to provide drug information, economic benefits, patient compliance, drug related problems (DRP), to determine the effect of patient counseling on quality of life of patient. METHODOLOGY- The prospective observational study to conducts for a period of two and half years about 30 months in patient departments in a tertiary care hospital in South India. promoting better medication use, ensuring that patients receive appropriate pharmacotherapy, thus minimizing the risk of unfavorable outcomes of pharmacotherapy adherence scale. RESULTS & DISCUSSION- A total of 1263 patients out of 6548 inpatients of general medicine department were followed out of which having one or more drug related problems. Female (56.7%) [Table-22] predominance was noted over males (43.3%). Drug related problems were more commonly seen in patients aged between 41-60 years, (47.92 %). A total of 240 drug related problems were identified. Most of the DRP observed in the study resulted from the inappropriate drug dosing problems (25.42%) followed by drug selection (24.16%)[Table-23]. Majority of the clinical pharmacist recommendations were on drug discontinuation (29.58%) and drug doses change (22.6%). CONCLUSION- The study concludes that involving clinical pharmacist services in patients care can significantly helps to identify, resolve and prevent the DRPs in the hospital thereby enhancing the patients outcomes. Furthermore, the suggestions provided by the clinical pharmacist during the intervention were well accepted by the physician thus the collaborative approach of physician and clinical pharmacist can provide better patients centre care outcomes. The study stresses the importance of clinical pharmacist in health care sector and impeccable role in patients care.

Article Highlights

The file does not exist in any folder.

Google Scholar

Pharmacist traditionally involving compounding, production and dispensing of drugs from ancient times. As the diseases and sedentary life style leads to complications to use of more medications to manage the disease and life style problems, this is the time to identify the unsafe and irrationalize medicine medical therapy has emerged. This has also contributed to clinical pharmacists being more involved in patient-centered pharmacotherapy. A large literature documents the multiple roles clinical pharmacists can play in a variety of health care settings. The main aim of the study is role of clinical pharmacist in modifying disease outcome by patient centered care in the medical wards.Clinical pharmacist role between physician and patient to provide drug information, economic benefits, patient compliance, drug related problems (DRP), to determine the effect of patient counseling on quality of life of patient. METHODOLOGY- The prospective observational study to conducts for a period of two and half years about 30 months in patient departments in a tertiary care hospital in South India. promoting better medication use, ensuring that patients receive appropriate pharmacotherapy, thus minimizing the risk of unfavorable outcomes of pharmacotherapy adherence scale. RESULTS & DISCUSSION- A total of 1263 patients out of 6548 inpatients of general medicine department were followed out of which having one or more drug related problems. Female (56.7%) [Table-22] predominance was noted over males (43.3%). Drug related problems were more commonly seen in patients aged between 41-60 years, (47.92 %). A total of 240 drug related problems were identified. Most of the DRP observed in the study resulted from the inappropriate drug dosing problems (25.42%) followed by drug selection (24.16%)[Table-23]. Majority of the clinical pharmacist recommendations were on drug discontinuation (29.58%) and drug doses change (22.6%). CONCLUSION- The study concludes that involving clinical pharmacist services in patients care can significantly helps to identify, resolve and prevent the DRPs in the hospital thereby enhancing the patients outcomes. Furthermore, the suggestions provided by the clinical pharmacist during the intervention were well accepted by the physician thus the collaborative approach of physician and clinical pharmacist can provide better patients centre care outcomes. The study stresses the importance of clinical pharmacist in health care sector and impeccable role in patients care.

EVALUATION OF ANTHELMINTIC ACTION OF EMBLICA OFFICINALIS LEAVES EXTRACT ON INDIAN EARTH WORM

Tanvi T. Sambre *1, Tushar K. Sambre 1, Shivprasad H. Majumdar 2

1Priyadarshani Yashodhara College of Pharmacy Chandrapur, Bangali Camp Mul Road Chandrapur.

2Satara College of Pharmacy, Satara.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights Download PDF (37) Google Scholar

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF ELIGLUSTAT USING RP-HPLC METHOD IN BULK AND PHARMACEUTICAL DOSAGE FORM

Amena Tazeen1*, Dr. R. Vani2, Dr. M. Sunitha3

1Department of Pharmaceutical Analysis and Quality Assurance, Shadan Women�s College Pharmacy, Hyderabad, India.

2Department of Pharmaceutical Analysis, Shadan Women�s College Pharmacy, Hyderabad, India.

3Principal of Shadan Women�s College Pharmacy, Hyderabad, India.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

AUTHENTICATION OF AYURVEDIC MEDICINE TRIKATU CHURNA USING NEAR INFRARED SPECTROSCOPY - A NOVEL APPROACH

Kumaravelu C1,2, Gopal A1, Ram Krishna Rao Mudiganti3*, Ravi A1, Singh Sanjay Kumar3, Shil Sampad3

1CSIR - Central Electronics Engineering Research Institute- Chennai Centre, CSIR Madras Complex, Chennai - 600 113, India.

2Sathyabama University, Chennai, 600 119, India.

3Bhartath Institute of Higher Education and Research, Bhartath University, Chennai, 600 073, India.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR THE DETERMINATION OF FIMASARTAN IN PRESENCE OF DEGRADATION PRODUCTS

Charu P. Pandya, Dr. Sadhana J.Rajput*

Quality Assurance Laboratory,Center of Relevance and Excellence in Novel Drug Delivery Systems, Faculty of Pharmacy, Shri. G.H. Patel Building, The Maharaja Sayajirao University of Baroda, Fatehgunj, Vadodara-390002, Gujarat, India.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

INSILICO ACTIVITY PREDICTION OF DIAZEPINES DERIVATIVES

P. Navya Krishna*

Dept. of Pharmaceutical Chemistry, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra-411044.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

INCIDENCE OF ADVERSE DRUG REACTIONS IN GERIATRIC PATIENTS IN A TERTIARY CARE HOSPITAL

Neena Baby*1, Neetha Sabu1, Lubna Sulthana1, Navya Sunil1, V.Lalitha2, T.Sivakumar1, Arun Pandiyan S3

1Nandha College of Pharmacy, Erode, Tamil Nadu, India.

2Department of Pharmacology, Nandha College of Pharmacy, Erode, Tamil Nadu, India.

3Clinical Pharmacist Kovai Medical College Hospital Coimbatore, Tamil Nadu, India.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF ORAL HYPOGLYCEMIC DRUG

Talat Farheen*1, Azmat Shaikh1, Dr. Zahid Zaheer1, Dr. Sadhana Shahi2

1Y.B. Chavan College of Pharmacy, Department of Pharmaceutics, Aurangabad-431001, Maharashtra, India.

2Government College of Pharmacy, Department of Pharmaceutics, Aurangabad-431005, Maharashtra, India.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

ENHANCED ORAL BIOAVAILABILITY OF NEBIVOLOL HYDROCHLORIDE THROUGH LIQUISOLID APPROACH: APPLICATION OF NOVEL EXCIPIENTS

Narender Naik G1*, Shaym Sunder R2

1Jyothishmathi Institute of Pharmaceutical Sciences, Karimnagar, India.

2University Institute of Chemical Technology, Osmania University, Hyderabad, India.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

SEMI SOLID DOSAGE FORMS MANUFACTURING: TOOLS, CRITICAL PROCESS PARAMETERS, STRATEGIES, OPTIMIZATION AND RECENT ADVANCES

Md. Amman Maqbool*, Manoj Kumar Mishra, Supriya Pathak, Adarsh Kesharwani, Anuradha Kesharwani

Shambhunath Institute of Pharmacy, Jhalwa, Allahabad, Uttar Pradesh-211012, India.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights Download PDF (79) Google Scholar

EFFECT OF CHRONIC EXPOSURE TO GSM 900/1800 MHZ RADIOFREQUENCY RADIATION ON GENERAL BLOOD PHYSIOLOGY AND REPRODUCTIVE FUNCTION IN MALE RATS

K. Chaithanya; Preeti. Kumari; Razdan. Rema; Devasani. Karan

Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore -560027, Karnataka, India.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights Download PDF (39) Google Scholar

ASSESSMENT OF IN VITRO ANTIOXIDANT AND ANTIHAEMOLYTIC ACTIVITIES IN TRITICUM AESTIVUM GRASS AND CARICA PAPAYA LEAVES

Sonia Johri*, Neha Khan

ITM University, AH-43, Jhansi Road, Gwalior, Madhya Pradesh 475001.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights Download PDF (63) Google Scholar

PLIGHTS AND PREDICAMENTS IN THE PHARMACY INDUSTRY

Neha Naaz1*, Khaja Uzair ul Hasan1, Aaminah Najmus Sahar1, Prof. Dr. Osman Ahmed2

1Deccan School of Pharmacy, Nampally, Hyderabad, India � 500001.

2Hyderabad, India-500001.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights Download PDF (63) Google Scholar

FORMULATION OF ANTIMALASSEZIC SHAMPOO FROM DATURA METEL AND PROSOPIS JULIFLORA

R. S. A. Sorna Kumar*, R. Amara Bharathi, R. Lakshmipriya, C. Suganya Devi, A. Sivaranjani, T. Banumathi,

Department of Biotechnology, Jeppiaar Engineering College, Chennai-600119, Tamil Nadu.

Department of Biotechnology, P.S.R Engineering College, Sivakasi-626140, Tamil Nadu

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

INCREASED RISK OF ENDOMETRIAL CARCINOMA AND ACCURACY IN THE DIAGNOSIS OF PATIENTS: A GYNECOLOGIC STUDY

Matta Jyothi Sravani, Guvvala Gayathri, A. Deevan Paul*

SVU College of Pharmaceutical Sciences, SV University, Tirupati- 517502.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN AND TENELIGLIPTIN IN BULK AND ITS DOSAGE FORM USING RP-HPLC

Kaneez Fatima*, Dr. R. Vani, Dr. M. Sunitha

Department of Pharmaceutical Analysis and Quality Assurance, Shadan Women�s College Pharmacy, Hyderabad,India.

Author Image

Graphical Abstract

Graphical Abstract

A new method was developed for simultaneous estimation of Teneligliptin and Metformin by RP-HPLC. The chromatographic conditions were successfully carried out on Inertsil ODS column C8 (4.6x250mm) of 5?m particle size, flow rate was 1.0ml/min, using mobile phase composed of 50% buffer: 50% Acetonitrile, detection wavelength used as 240 nm. The instruments and materials used were WATERS, software: Empower, 2695 separation module.2487 UV detector, UV/VIS spectrophotometer-LABINDIA UV 3000+. The retention time was found to be for Metformin 3.608 min and for Teneligliptin 5.148 min. The assay of Metformin and Teneligliptin was performed with tablets and the % assay was found to be 99.97 and 100.64 which shows that the method is useful for routine analysis. The linearity of Metformin and Teneligliptin was found to be linear with a correlation coefficient of 0.999 and 0.999, which shows that the method is capable of producing good sensitivity.The acceptance criteria of precision is RSD should be not more than 2.0% and the method show precision 0.4 and 0.8 for Metformin and Teneligliptin which shows that the method is precise.The acceptance criteria of intermediate precision is RSD should be not more than 2.0% and the method show precision 0.1 and 0.7 for Metformin and Teneligliptin which shows that the method is repeatable when performed in different days also. The accuracy limit is the percentage recovery should be in the range of 97.0% - 103.0%. The total recovery was found to be 99.86% and 99.96% for Metformin and Teneligliptin. The validation of developed method shows that the accuracy is well within the limit, which shows that the method is capable of showing good accuracy and reproducibility. The acceptance criteria for LOD and LOQ is 3 and 10. The LOD and LOQ for Metformin was found to be 3.00 and 9.98 and LOD and LOQ for Teneligliptin was found to be 3.02 and 10.00. The linearity of Teneligliptin and Metformin was found to be linear with a correlation coefficient of (R2) 0.998 and 0.999 respectively. The robustness limit for mobile phase variation and flow rate variation are well within the limit, which shows that the method is having good system suitability and precision under given set of conditions. The analytical method was validated according to ICH Guidelines.

Article Highlights Download PDF (73) Google Scholar

A new method was developed for simultaneous estimation of Teneligliptin and Metformin by RP-HPLC. The chromatographic conditions were successfully carried out on Inertsil ODS column C8 (4.6x250mm) of 5?m particle size, flow rate was 1.0ml/min, using mobile phase composed of 50% buffer: 50% Acetonitrile, detection wavelength used as 240 nm. The instruments and materials used were WATERS, software: Empower, 2695 separation module.2487 UV detector, UV/VIS spectrophotometer-LABINDIA UV 3000+. The retention time was found to be for Metformin 3.608 min and for Teneligliptin 5.148 min. The assay of Metformin and Teneligliptin was performed with tablets and the % assay was found to be 99.97 and 100.64 which shows that the method is useful for routine analysis. The linearity of Metformin and Teneligliptin was found to be linear with a correlation coefficient of 0.999 and 0.999, which shows that the method is capable of producing good sensitivity.The acceptance criteria of precision is RSD should be not more than 2.0% and the method show precision 0.4 and 0.8 for Metformin and Teneligliptin which shows that the method is precise.The acceptance criteria of intermediate precision is RSD should be not more than 2.0% and the method show precision 0.1 and 0.7 for Metformin and Teneligliptin which shows that the method is repeatable when performed in different days also. The accuracy limit is the percentage recovery should be in the range of 97.0% - 103.0%. The total recovery was found to be 99.86% and 99.96% for Metformin and Teneligliptin. The validation of developed method shows that the accuracy is well within the limit, which shows that the method is capable of showing good accuracy and reproducibility. The acceptance criteria for LOD and LOQ is 3 and 10. The LOD and LOQ for Metformin was found to be 3.00 and 9.98 and LOD and LOQ for Teneligliptin was found to be 3.02 and 10.00. The linearity of Teneligliptin and Metformin was found to be linear with a correlation coefficient of (R2) 0.998 and 0.999 respectively. The robustness limit for mobile phase variation and flow rate variation are well within the limit, which shows that the method is having good system suitability and precision under given set of conditions. The analytical method was validated according to ICH Guidelines.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF ETELCALCETIDE IN BULK AND ITS DOSAGE FORM USING RP-HPLC

Shabana Sultana1*, Dr R. Vani 2, Dr M. Sunitha3

1Department of Pharmaceutical Analysis and Quality Assurance, Shadan Women�s College of Pharmacy, Hyderabad.

2Department of Pharmaceutical Analysis, Shadan Women�s College of Pharmacy, Hyderabad.

3Shadan Women�s College of Pharmacy, Hyderabad.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

FORMULATION AND EVALUATION OF COLON TARGETED pH DEPENDENT MICROCAPSULES OF Nigella sativa L. EXTRACT FOR COLORECTAL CANCER

Afsana Nazeer*, Neema George

Department of Pharmaceutics, Department of Pharmaceutical sciences, Centre for Professional and Advanced Studies, Rubber board P.O, Kottyam-686009, Kerala.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

A VALIDATED SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF AMBROXOL HYDROCHLORIDE AND LEVOCETIRIZINE DIHYDROCHLORIDE IN TABLET FORMULATIONS

Mr. G. K. Dyade

SVPM�s College of Pharmacy,Malegaon(BKII), Tal. Baramati Dist. Pune 413115

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

CHARACTERIZATION AND EVALUATION OF ANTIOXIDANT ACTIVITY OF OCIMUM CANUM LEAVES AND ITS EFFECIENCY ON SCHISTOSOMA MANSONI LARVAL STAGE

Heba Abdel-Hady, Mahfouz Mohamed Abdel-Gawad and Eman Ahmed El-Wakil

Medicinal Chemistry Laboratory, Theodor Bilharz Research Institute, Warrak El-Hader, Giza, Egypt.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights Download PDF (54) Google Scholar

DETERMINATION OF BIO PHARMACEUTICAL COMPONENTS OF A NOVEL POLY HERBAL FORMULATION BY GC MS ANALYSIS.

S. Selvakumar*, J. Sindhuja

Department of Industrial BioTechnology, Bharath University, Chennai-600073, India

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

METHOD DEVELOPMENT AND VALIDATION OF HYDRALAZINE HYDROCHLORIDE BY USING UV AND RP-HPLC

Ms. M. Monika1,2*, B. Swathi1, Md. Faheemuddin2

1School of Pharmacy (Formerly Lalitha College of Pharmacy), Anurag Group of Institutions, Venkatapur, Ghatkesar, Ranga Reddy Dist. -501 301, INDIA.

2Smt. Sarojini Ramulamma College of Pharmacy, Seshadrinagar, Mahabubnagar-509001.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights Download PDF (81) Google Scholar

PHYTOCHEMICAL EXTRACTION OF STEM OF SIDA ACUTA BURM. F.

Mushraf Qureshi, Mukta Shrivastava

Department of Botany, Govt. M. L.B. Girls P.G. (Autonomous) College, Bhopal; 462002. M.P. India.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar

SYNTHESIS AND ANTI-BACTERIAL ACTIVITY OF SOME NOVEL PYRAZOLIDINEDIONE SUBSTITUTED DERIVATIVES OF 2-QUINOLONES

Syed Hafeez Ahmed1, Haney Ahmed2, Syed Habeeb Ali2, Sabiha Fatima2, Shafia Hyder2, Amjad Pasha2

1Department of Pharmaceutical Analysis and Quality Assurance, Shadan College of Pharmacy, Peeran Cheru, Hyderabad.

2Department of Chemistry, Shadan College of Pharmacy, Peeran Cheru, Hyderabad.

Author Image

Graphical Abstract

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Google Scholar