Abstract
The present work describes one pot synthesis of 2-acetyl-1-naphthol (3a), 6-hydroxy tetracene-5-12-dione (3b) and 7-acetyl-6-hydroxytetracene-5-12-dione(3c) through Friedel-Crafts reaction followed by Fries rearrangementby using starting materials phthalic anhydride and 1-naphthylacetate in presence of anhydrous aluminum chloride. The products thus obtained were characterized using spectroscopic techniques and screened for their antimicrobial and anticancer activities. An attempt is also made to synthesize the flavone derivatives of the obtained products. The products 2-acetyl-1-naphthol and 7-acetyl-6-hydroxytetracene-5-12-dione shows a range of antimicrobial activity against the pathogens Paratyphi-A and Aspergillus niger and prominent anticancer activity against Dalton’s Lymphoma Ascites (DLA) cells, which has been carried out using MTT assay and by trypan blue dye exclusion method. Tested compounds 3a and 3c were found to be active against the pathogens in milligram concentration. Compound 3b was found to be show highest anticancer activity (80 % toxicity) against DLA cells.
