Abstract

The main aim of the study is to formulate the floating tablets of cefaclor drug by using the polymers such as HPMC K15M,K100M and Carbopol 934P  which were prepared by direct compression technique.The tablets were prepared by varying the concentrations of polymers. The drug polymer compatibility was studied by FTIR studies.The tablets were evaluated by weight variation, hardness, Friability,drug content, In Vitro buoyancy studies, Swelling studies & In vitro dissolution studies. No significant drug polymer interactions were observed in FTIR studies. In vitro drug release profile of cefaclor tablets was examined in pH 0.1N HCl for the 12 hrs and the percentage drug release was found to be 94.91%.The formulated tablets had shown higher percentage drug release by the optimized formulation F11,better swelling and buoyancy.By the stability studies there are no significant difference in formulations F11 and the kinetic studies such as Zero order Plot, First order plot, Higuchi’s Plot and Korsemeyer Peppa’s plot .By the applying kinetic studies to the In vitro drug release which follows korsemeyer Peppa’s and showss anomalous type or non Fickian diffusion.