Abstract

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery.  Oro dispersible tablets are the fast growing and highly accepted drug delivery system now a day’s mainly to improve patient compliance. In recent years superdisintegrants have been employed to develop effectual mouth dissolving tablets & to overcome limitation of conventional tablets, which is because of their convenience in administration and suitability for patients having dysphagia. It is suited for tablets undergoing high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to minimize side effect and make it more cost effective. Clopidogrel Bisulphate is an oral, thienopyridine class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. The objective of the present investigation was to prepare Oro dispersible tablets of Clopidogrel Bisulphate by using Solid Dispersion technique; sodium starch glycolate, Croscarmellose sodium and CrosspovidoneXL-10 were used as superdisintegrants in combinations to achieve optimum release profile, disintegration time and hardness. The tablets were formulated by Solid Dispersion technique and the fabricated tablets were evaluated for various micromeritic properties like bulk density, tapped density, compressibility index, Hausner’s ratio, angle of repose and post compression characteristics like thickness, hardness, friability, disintegration time, drug release, drug content, water absorption ratio, wetting time, in-vitro drug release. The drug and excipients compatibility study was performed by FTIR to study the interaction between drug and excipients FTIR studies and short term stability studies. The tablets prepared by solid dispersion technique posses a weight variation in the range 290 to 310mg which is below ±7.5%, hardness of 2.00 kg/cm2to 4.5kg/cm2, disintegration time 10 to 20sec in-vitro drug release showed 98.42% within 10mins.Hence the above said formulation can be upgraded for further research studies and can be made available to common man after all the clinical trials.