Abstract
RP-HPLC stability indicating method was developed for determining Ketorolac in pharmaceutical formulations and its degradation products using C8 column with the mobile phase containing mixture of buffer (water [45] + glacial acetic acid [10 ml]: Methanol in the ratio of 35:65 v/v/v at a flow rate of 1.0 ml/min was found to yield satisfactory retention time of about 5.321 min with sharp symmetrical peak at a detection wavelength of 254 nm. The method was validated using ICH guidelines and was found to be linear in the range 0.1-0.5 µg/ mL. The methos proposed shows good separation of Ketorolac and its degradation products. The developed method can be applied successfully for the determination of Ketorolac.
