Abstract
Androgen Insensitivity syndrome is a rare disorder specifically affecting the male gender during their development stages, viz., the period after their birth and most commonly seen during the puberty age. This condition is characterized by the incompetence of the cells of a male human to respond to the stimulus of the male sex hormone (collectively termed as androgens) normally. As a consequence of this, the male person affected by this syndrome might possess some features which are characteristic to females besides having some features of males as well. This condition predominantly affects male homosapiens (i.e., the humans whose genetic makeup comprises of the possession of one X chromosome and one Y chromosome), whose abnormal inheritance is cited as the reason behind this syndrome. Furthermore studies revealed that this abnormality, perceived exclusively in X chromosome only, is owed to certain mutations in an explicit gene known as AR (androgen receptor) gene. The results of the inheritance of such abnormal or mutated genes is inability of the male to accomplish the complete process of masculinization during the puberty age which may lead to the development of mixed gender features, which sometimes becomes a source of embarrassment and might create some really awkward situations for the affected person, especially in such insensitive stereotyped society, such as India, where non-conventional gender system has not yet found respectable acceptance. The various researches conducted for exploring this disorder in detail revealed numerous mutations in the concerned gene which are held responsible for its pathophysiology. These discovered mutations could lead to the evolvement of future aspects which could potentially be utilized for the better understanding of this disorder and probably finding a way for its management.
