Abstract
Present investigation deals with the study of the effect of Cyclophosphamide (CP), a widely used anticancer and immunosuppressive drug, on the histological changes in testis of Rattus rattus. Adult male rats were injected with CP at the level of 40mg/kg body weight alternately for 15 days. This chemotherapeutic drug is delivered intraperitonially up to 15 days. Testis of Rattus rattus treated up to 15 days with low dose (40mg/kg body weight) of Cyclophosphamide (CP) showing several histological alteration including less number of spermatozoa in lumen (reduction in the number of spermatozoa). Disorganized spermatogenic cells with reduced number of spermatids. Leydig cells are also prominent and lumens are filled with relatively less number of spermatozoa.
