Abstract
Diabetes Mellitus (DM) is a group of metabolic disorder characterized by hyperglycemia resulting from defects of insulin secretion or increased cellular resistance to insulin. When abnormal glucose levels, whether too high or too low, can cause seizures. The problem is especially pertinent to individuals with diabetes, whose blood glucose levels can fluctuate widely over the course of a day, as a result of intercurrent illness, variations in insulin levels, or other metabolic factors.A convulsion is an abnormal violent and involuntary or series of contractions of the muscles. It occurs when the brain cells become too active and disorganized in their electrical properties. Though very less number of cases of diabetes associated with convulsions is reported, the risk of the mortality and morbidity increased due to the associated condition. For efficacious and safe therapy of diabetes associated with convulsion the study of interaction between OHAs (oral hypoglycemic agent) and Anticonvulsant is needed. Most commonly preferred oral hypoglycemic agent (metformin & glipizide) & anticonvulsant (Gabapentin) were selected for studied. Effect of combination of above drug on WBC’S, BODY WT, GHb, BSL and SCL were evaluated. Results obtained in study indicates more significant reduction (P<0.001) in glycemic control by combination of glipizide & Gabapentin as compared with combination of Metformin with Gabapentin and single administration with Gabapentin , metformin & glipizide & also significantly (P<0.001) change in hematological parameters ,body weight was observed in group treated with combination of glipizide & Gabapentin as compared with combination of Metformin with Gabapentin and single administration with Gabapentin , metformin & glipizide.
