Abstract

In the present study, a series of semicarbazones were synthesized from substituted anilines and evaluated for their anticonvulsant and antimicrobial activities. The anticonvulsant activities were established by using experimental animal, albino mice and rats (150-250 gm) and screened against electroshock seizure. T₁ came out to be the best synthesized compound against epilepsy among all newly synthesized compounds in MES test. The antibacterial activity of newly synthesized 4-(4-substituted aryl) semicarbazones evaluated against gram (+)ve bacteria viz Bacillus subtillis and gram (-)ve bacteria viz Escherichia coli. Results signify that semicarbazones are potential antibacterial agents and T₂ came out to be the best synthesized compound against B.subtillis at concⁿ 50 µg/ml and 100 µg/ml with 83.33% and 82.14% activity respectively while T₃ came out to be the best synthesized compound against E.coli at 50 µg/ml concⁿ with 84.61% activity. The antifungal activity of newly synthesized 4-(4-substituted aryl) semicarbazones evaluated against two micro-organisms Aspergillus niger and Penicillium marneffei. Results of the antifungal assay elicited that T₂ and T₃ gave the same and maximum activity against A.niger at 50 µg/ml concⁿ with 77.77% activity while T₂ gave 84.21% activity against P.marneffei at 100 µg/ml concⁿ. This study has highlighted the importance of distal alkyl chain which influences the anticonvulsant activity

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