Tinospora cordifolia commonly known as “Gulvel” is known for its vast application in the treatment of various diseases in the traditional ayurvedic literature.The plant also possesses various pharmacological activity including its use as antihyperglycemic, anti-inflammatory, Antiarthmetic and osteoporotic, enhance cognition, antidiarrheal and immunomodulatory effects.Tinospora cordifolia contains phytochemicals constituent such as alkaloids, diterpenoids lactones, glycosides, steroids, sesquiterpenoids, phenolics, aliphatic compounds and polysaccharide. T.cordifolia considered as an important herbal drug of Indian System of Medicinces (ISM). The herb is known for its therapeutic efficacy and used in treatment of dyspepsia, diabetes, fever, urinary problems, jaundice, chronic diarrhea, cardiac disease, dysentery, helmenthiasis, skin diseases, leprosy and many more diseases. Present review highlights the classical antitoxin,anti-diabetic, anticancer, immunomodulatory, antioxidant, antimicrobial, hepatoprotective activity of Guduchi and their validation through existing literature. The plant is reported to contain alkaloids, glycosides, steroids and terpenoids.The current study is under-taken to explore and establish the phytochemistry and pharmacological activity of T.cordifolia.