AIM AND OBJECTIVE: Theaim of the study was to Insights into resistance and sensitivity patterns of various uropathogens and their management in urinary tract infections RESULTS: The study included 221 UTI patients reports revealed that males accounted for 50.2% and females 49.7%, respectively. Escherichia coli (31.2%) was the most common and Proteus mirabilis (1.35%) was the least often found organism to cause UTIs, with the addition of klebsiella pneumonia (24.8%), and pseudomonas aeruginosa (12.2%) playing their role in causing UTIs. The gram-negative uropathogens accounted for 78.2% which caused more UTIs, followed by Gram-positive bacteria at 18.55% and fungi at 3.16%. Tigecycline (76.9%) was shown to be the most sensitive antibiotic, were as ciprofloxacin (72.3%) was the most frequently seen drug that showed resistance to uropathogens. E. coli was found to be resistant to ciprofloxacin (72.4%), but sensitive to tigecycline (95.6%). Pseudomonas aeruginosa was found to be resistant to trimethoprim/sulfamethoxazole (86.6%, but sensitive to Colistin (83.3%). Klebsiella pneumonia was found to be resistant to ciprofloxacin (67.2%) and sensitive to colistin and tigecycline (85.4%). Enterococcus species were found to be resistant to ciprofloxacin (94.5%), but sensitive to tigecycline (100%). CONCLUSION: According to the study, tigecycline was the most sensitive antibiotic while ciprofloxacin was the most resistant antibiotic. It was also identified that the most common probable causative organism was found to be E. coli.