The skin is the largest organ of the human body, protecting it from the external environment. Despite their strong self-regeneration capability, severe skin abnormalities do not heal on their own and must be covered with skin substitutes. Silk fibroin has the potential to be used in tissue engineering. We discuss our opinion of its utility as a biomaterial for tissue reconstruction in diverse organs, with a particular emphasis on wound healing. We cover the various methods for preparing regenerated silk fibroin, as well as their benefits and drawbacks, in addition to the key scaffold systems for wound management. We conclude that fibroin is a promising choice for further research due to its strength, structural flexibility, biocompatibility, biodegradability, and potential for modification.